Six new cadinane-type sesquiterpenoids from the leaves of Chimonanthus nitens Oliv

被引：6

作者：

Guo, Na ^{[1
]}

Shu, Qi-bang ^{[2
]}

Zhang, Peng-yao ^{[1
]}

Fu, Jian-jiang ^{[1
]}

Wan, Yi-li ^{[1
]}

Wang, Xiao-min ^{[3
]}

Shu, Ren-geng ^{[1
]}

机构：

[1] Jiangxi Univ Chinese Med, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China

[2] Jiangxi Prov Food & Drug Adm, Nanchang 330029, Jiangxi, Peoples R China

[3] Jiangxi Univ Chinese Med, Sch Life Sci, Nanchang 330004, Jiangxi, Peoples R China

来源：

FITOTERAPIA | 2021年 / 154卷

基金：

中国国家自然科学基金;

关键词：

Chimonanthus nitens Oliv; Cadinane; Sesquiterpenoids; Cytotoxicity;

D O I：

10.1016/j.fitote.2021.105019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new cadinane-type sesquiterpenoids, named Chimnitensin A-F (1-6) were isolated from the leaves of Chimonanthus nitens Oliv. Their structures were elucidated by comprehensive spectroscopic analyses and comparison with structurally related known analogues. In vitro MTT assay showed that all six compounds had cytotoxicity against two selected human breast cancer cell lines (MDA-MB-468 and MDA-MB-231), which indicate their potential of developing into anticancer drugs.

引用

页数：5

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