Autophagy in the Cellular Energetic Balance

被引：670
作者：
Singh, Rajat [1 ,3 ,5 ]
Cuervo, Ana Maria [1 ,2 ,4 ,5 ]
机构：
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[4] Yeshiva Univ Albert Einstein Coll Med, Inst Aging Studies, Bronx, NY 10461 USA
[5] Yeshiva Univ Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10461 USA
来源：
CELL METABOLISM | 2011年 / 13卷 / 05期
关键词：
PANCREATIC BETA-CELL; RAT-LIVER; SELECTIVE AUTOPHAGY; CONJUGATION SYSTEM; HEPATIC AUTOPHAGY; PROTEIN-SYNTHESIS; AMINO-ACIDS; MTOR; PHOSPHORYLATION; DEPRIVATION;
D O I：
10.1016/j.cmet.2011.04.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.
引用
收藏
页码：495 / 504
页数：10
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