Cationic Two-Photon Lanthanide Bioprobes Able to Accumulate in Live Cells

被引：44

作者：

Bui, Anh Thy ^{[1
]}

Beyler, Maryline ^{[2
]}

Liao, Yuan-Yuan ^{[1
]}

Grichine, Alexei ^{[3
]}

Duperray, Alain ^{[3
]}

Mulatier, Jean-Christophe ^{[1
]}

Le Guennic, Boris ^{[4
]}

Andraud, Chantal ^{[1
]}

Maury, Olivier ^{[1
]}

Tripier, Raphael ^{[2
]}

机构：

[1] Univ Lyon 1, ENS Lyon, CNRS, Lab Chim,UMR 5182, 46 Allee Italie, F-69364 Lyon, France

[2] Univ Brest, UMR CNRS 6521, UFR Sci & Tech, 6 Ave Victor le Gorgeu,CS 93837, F-29238 Brest 3, France

[3] Univ Grenoble Alpes, INSERM, U1209, IAB, F-38000 Grenoble, France

[4] Univ Rennes 1, UMR CNRS 6226, Inst Sci Chim Rennes, Ave Gen Leclerc, F-35042 Rennes, France

来源：

INORGANIC CHEMISTRY | 2016年 / 55卷 / 14期

关键词：

EUROPIUM COMPLEXES; LUMINESCENCE; MICROSCOPY; TERBIUM; EXCITATION; TRIAZACYCLONONANE; EMISSION; LIGANDS; NUMBER;

D O I：

10.1021/acs.inorgchem.6b00891

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An original cationic water-soluble cyclen-based Eu(III) complex [EuL1](+) featuring a chromophore-functionalized antenna to increase the two-photon (2P) absorption properties was synthesized. The photophysical properties were thoroughly studied in various solvents and rationalized with the help of theoretical calculations. The complex exhibits an optimized 2P absorption cross section. Finally, 2P microscopy imaging experiments on living T24 human cancer cells highlighted the spontaneous internalization and the biological stability of this 2P bioprobe in vitro. Macrocyclic-based antennas open new perspectives for future optimization of the photophysical properties and allows envisaging the design of Eu, Tb, Yb, and Sm bioprobes. This result also opens the way for the design of functional two-photon Ln complexes able to monitor intracellular physicochemical parameters.

引用

页码：7020 / 7025

页数：6

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