Progress in Metabonomics of Type 2 Diabetes Mellitus

被引：54
|
作者：
Ma, Quantao [1 ]
Li, Yaqi [1 ]
Wang, Min [1 ]
Tang, Ziyan [1 ]
Wang, Ting [2 ]
Liu, Chenyue [1 ]
Wang, Chunguo [3 ]
Zhao, Baosheng [3 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
[2] Natl Inst Food & Drug Control, Natl Ctr Safety Evaluat Drugs, Beijing 100176, Peoples R China
[3] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing 100029, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
type 2 diabetes mellitus; metabonomics; biomarkers; metabolic pathways; INSULIN-RESISTANCE; SKELETAL-MUSCLE; TRANSSULFURATION PATHWAY; METABOLIC MARKERS; OXIDATIVE STRESS; ACID-METABOLISM; AMINO-ACIDS; PATHOGENESIS; RISK; GLUCOSE;
D O I：
10.3390/molecules23071834
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet. Metabonomics techniques are used to study the changes of metabolites and metabolic pathways before and after the onset of diabetes and make it more possible to further understand the pathogenesis of T2DM and improve its prediction, early diagnosis, and treatment. In this review, we summarized the metabonomics study of T2DM in recent years and provided a theoretical basis for the study of pathogenesis and the effective prevention and treatment of T2DM.
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页数：18
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