The Therapeutic Effect of Second Near-Infrared Absorbing Gold Nanorods on Metastatic Lymph Nodes via Lymphatic Delivery System

被引：7

作者：

Oladipo, Adewale O. ^{[1
,2
]}

Lebepe, Thabang C. ^{[1
,2
]}

Ncapayi, Vuyelwa ^{[1
,2
]}

Tsolekile, Ncediwe ^{[1
,2
]}

Parani, Sundararajan ^{[1
,2
]}

Songca, Sandile P. ^{[3
]}

Mori, Shiro ^{[4
,5
]}

Kodama, Tetsuya ^{[4
]}

Oluwafemi, Oluwatobi S. ^{[1
,2
]}

机构：

[1] Univ Johannesburg Doornfontein Campus, Dept Chem Sci, ZA-2028 Johannesburg, South Africa

[2] Univ Johannesburg, Ctr Nanomat Sci Res, ZA-2028 Johannesburg, South Africa

[3] Univ KwaZulu Natal, Dept Chem, Private Bag X 54001, ZA-4000 Durban, South Africa

[4] Tohoku Univ, Grad Sch Biomed Engn, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan

[5] Tohoku Univ Hosp, Dept Oral & Maxillofacial Surg, 1-1 Seiryo, Sendai, Miyagi 9808575, Japan

来源：

PHARMACEUTICS | 2021年 / 13卷 / 09期

基金：

芬兰科学院; 新加坡国家研究基金会;

关键词：

lymphatic route; gold nanorods; photothermal therapy; metastatic lymph node; near-infrared light; PHOTOTHERMAL THERAPY; CYTOTOXICITY; IMPROVE; TUMORS; MODEL;

D O I：

10.3390/pharmaceutics13091359

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Photothermal therapy has been established recently as a non-invasive treatment protocol for cancer metastatic lymph nodes. Although this treatment approach shows efficient tumour ablation towards lymph node metastasis, the monitoring and reporting of treatment progress using the lymphatic delivery channel still need to be explored. Herein, we investigated the anti-tumour effect of pegylated gold nanorods with a high aspect ratio (PAuNRs) delivered via the lymphatic route in a mouse model. In this study, breast carcinoma (FM3A-Luc) cells were inoculated in the subiliac lymph node (SiLN) to induce metastasis in the proper axillary lymph node (PALN). The treatment was initiated by injecting the PAuNRs into the accessory axillary lymph node (AALN) after tumour metastasis was confirmed in the PALN followed by external NIR laser irradiation under a temperature-controlled cooling system. The anti-tumour impact of the treatment was evaluated using an in vivo bioluminescence imaging system (IVIS). The results showed a time-dependent reduction in tumour activity with significant treatment response. Tumour growth was inhibited in all mice treated with PAuNRs under laser irradiation; results were statistically significant (** p < 0.01) even after treatment was concluded on day 3. We believe that this non-invasive technique would provide more information on the dynamics of tumour therapy using the lymphatically administered route in preclinical studies.

引用

页数：12

共 40 条

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