Significance of Endogenous Antimicrobial Peptides on the Health of Food Animals

被引：8
作者：
Fasina, Yewande O. [1 ]
Obanla, Temitayo [1 ]
Dosu, George [1 ]
Muzquiz, Sierra [1 ]
机构：
[1] North Carolina Agr & Tech State Univ, Dept Anim Sci, Greensboro, NC 27411 USA
来源：
FRONTIERS IN VETERINARY SCIENCE | 2021年 / 8卷
基金：
美国农业部;
关键词：
antimicrobial peptide; food animals; host immune system; antimicrobial resistance; gut health; BETA-DEFENSIN; EXPRESSION; CATHELICIDIN; RESISTANCE; FISH; MECHANISMS; HEPCIDIN; ANTIBACTERIAL; PERFORMANCE; HOMEOSTASIS;
D O I：
10.3389/fvets.2021.585266
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Acquired resistance to in-feed antibiotic growth promoters continues to be an imperative problem in the livestock industries, thereby necessitating continuous pursuit for alternatives. Antimicrobial peptides (AMPs) represent a critical part of the host's innate immune system and have been documented to have immunomodulatory activity. Increasing research evidence suggests that in contrast to antibiotics, AMPs exert broad-spectrum antibacterial activity in a manner that reduces bacterial acquisition of resistance genes. This review summarizes current knowledge on the protective effects of endogenous (natural) AMPs in the gastrointestinal tract of food animals. Factors limiting the efficacy of these AMPs were also discussed and mitigating strategies were proposed.
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页数：8
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