Brain Natriuretic Peptide Biomarkers in Current Clinical and Therapeutic Scenarios of Heart Failure

被引:27
作者
Alcidi, Gianmarco [1 ,2 ]
Goffredo, Giovanni [1 ,2 ]
Correale, Michele [1 ,2 ]
Brunetti, Natale Daniele [1 ,2 ]
Iacoviello, Massimo [1 ,2 ]
机构
[1] Univ Foggia, Dept Med & Surg Sci, Viale Luigi Pinto 1, I-71122 Foggia, Italy
[2] Polyclin Univ Hosp Riuniti Foggia, Cardiol Unit, Viale Luigi Pinto 1, I-71122 Foggia, Italy
关键词
brain natriuretic peptide; heart failure; diagnosis; prognosis; therapy; RECEPTOR NEPRILYSIN INHIBITION; REDUCED EJECTION FRACTION; GUIDED THERAPY; NT-PROBNP; BNP; MANAGEMENT; CARE; HOSPITALIZATION; PREDICT; RISK;
D O I
10.3390/jcm11113192
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Brain natriuretic peptide (BNP) and its inactive N-terminal fragment, NT-proBNP, are serum biomarkers with key roles in the management of heart failure (HF). An increase in the serum levels of these peptides is closely associated with the pathophysiological mechanisms underlying HF such as the presence of structural and functional cardiac abnormalities, myocardial stretch associated with a high filling pressure and neuro-hormonal activation. As BNP and NT-proBNP measurements are possible, several studies have investigated their clinical utility in the diagnosis, prognostic stratification, monitoring and guiding therapy of patients with HF. BNP and NT-proBNP have also been used as criteria for enrollment in randomized trials evaluating the efficacy of new therapeutic strategies for HF. Nevertheless, the use of natriuretic peptides is still limited in clinical practice due to the controversial aspect of their use in different clinical settings. The purpose of this review is to discuss the main issues associated with using BNP and NT-proBNP serum levels in the management of patients with HF under current clinical and therapeutic scenarios.
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页数:16
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