A comprehensive program of cognitive stimulation with digital inclusion, physical activity and social interaction can modify BDNF levels and improve cognition in adults over 50: a randomized controlled pilot study

被引:10
作者
Quialheiro, Anna [1 ,2 ,3 ]
Bobinski, Francine [4 ]
Haefliger, Jessica de Godoy [2 ]
Del Antonio, Renata [5 ]
Lins, Elisa Flores [4 ]
Martins, Daniel Fernandes [4 ]
d'Orsi, Eleonora [1 ]
Xavier, Andre Junqueira [1 ,6 ]
Peres, Marco Aurelio [7 ]
机构
[1] Fed Univ Santa Catarina UFSC, Postgrad Program Publ Hlth, Florianopolis, SC, Brazil
[2] Univ Southern Santa Catarina UNISUL, Physiotherapy Course, Palhoca, Brazil
[3] Univ Minho, Med Sch, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
[4] Univ Southern Santa Catarina UNISUL, Postgrad Program Hlth Sci, Expt Neurosci Lab LaNex, Palhoca, Brazil
[5] Hosp Fed Univ Santa Catarina UFSC, Florianopolis, SC, Brazil
[6] Univ Southern Santa Catarina UNISUL, Med Course, Palhoca, Brazil
[7] Duke NUS Med Sch, Hlth Serv & Syst Res Programme, Natl Dent Res Inst Singapore, Natl Dent Ctr Singapore,Oral Hlth ACP, Singapore, Singapore
关键词
Cognitive stimulation; biomarkers; neuroplasticity; digital inclusion; MENTAL-STATE-EXAMINATION; OLDER-ADULTS; NEUROTROPHIC FACTOR; PLASMA-LEVELS; IMPAIRMENT; DEMENTIA; EXERCISE; HEALTHY; TOOLS; MCI;
D O I
10.1080/13607863.2021.1966742
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives To analyze the effect of a comprehensive program of cognitive stimulation with digital inclusion, physical activity and social interaction, called "Oficina da Lembranca" (OL), on the cognitive status and concentration of biomarkers of neuroplasticity, neurodegeneration in adults aged 50 years and over attending a Memory Clinic. Methods In this pilot randomized controlled study, 64 patients without dementia aged 45 to 79 years, seen at a University Memory Clinic in Southern Brazil, were randomly allocated to the intervention and control groups. The intervention consisted of participation in OL for 12 weeks. Serum biomarkers (brain-derived neurotrophic factor [BDNF], S100 beta, and neuron-specific enolase [NSE]) and cognitive status were analyzed as primary and secondary outcomes. The Wilcoxon test and Generalized Estimating Equations (GEE) were applied. Results Of the 64 patients invited to participate in the study, 33 (intervention: 17, control: 16) completed the study with all data. Improvement of cognitive status was significant in the intervention group (22.6 to 24.5) but not in the control group (20.1 to 21.1). There was a significant reduction of BDNF in OL participants, but no significant change was observed in the neurodegenerative biomarkers S100 beta or NSE. The concentration of BDNF decreased significantly post-OL in the intervention group (-288.1, 95%CI -362.1 to -94.1), even after adjusting for sex, age, and educational level. Cognitive status was significantly improved in OL participants. Conclusion The OL program improved cognitive status, reduced serum BDNF levels, and empowered digitally excluded older adults. There was no effect of this intervention on S100 beta or NSE.
引用
收藏
页码:1979 / 1987
页数:9
相关论文
共 60 条
[1]   Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda [J].
Abassi, Mahsa ;
Morawski, Bozena M. ;
Nakigozi, Gertrude ;
Nakasujja, Noeline ;
Kong, Xiangrong ;
Meya, David B. ;
Robertson, Kevin ;
Gray, Ronald ;
Wawer, Maria J. ;
Sacktor, Ned ;
Boulware, David R. .
JOURNAL OF NEUROVIROLOGY, 2017, 23 (03) :369-375
[2]  
ABDULRAHMAN SA, 2013, LIFE SCI J, V10, P2634
[3]   Vestibular and balance treatment of the concussed athlete [J].
Aligene, Kathy ;
Lin, Emerald .
NEUROREHABILITATION, 2013, 32 (03) :543-553
[4]  
American Psychiatric Association, 2014, MAN DIAGN EST DIST M
[5]  
Angelucci Francesco., 2009, CURR ALZHEIMER RES, V999, P1, DOI [10.2174/1567209197155462050, DOI 10.2174/1567209197155462050]
[6]   Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI) [J].
Arevalo-Rodriguez, Ingrid ;
Smailagic, Nadja ;
Roque i Figuls, Marta ;
Ciapponi, Agustin ;
Sanchez-Perez, Erick ;
Giannakou, Antri ;
Pedraza, Olga L. ;
Bonfill Cosp, Xavier ;
Cullum, Sarah .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (03)
[7]   Long term habitual exercise is associated with lower resting level of serum BDNF [J].
Babaei, Parvin ;
Damirchi, Arsalan ;
Mehdipoor, Mohammad ;
Tehrani, Bahram Soltani .
NEUROSCIENCE LETTERS, 2014, 566 :304-308
[8]   Health status and physical activity levels among the elderly who are participants and non-participants in social welfare groups in Florianopolis [J].
Bertoldo Benedetti, Tania Rosane ;
Mazo, Giovana Zarpellon ;
Borges, Lucelia Justino .
CIENCIA & SAUDE COLETIVA, 2012, 17 (08) :2087-2093
[9]   Digital Screening for Cognitive Impairment - A Proof of Concept Study [J].
Bloniecki, V ;
Hagman, G. ;
Ryden, M. ;
Kivipelto, M. .
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2021, 8 (02) :127-134
[10]   PET and MRI Reveal Early Evidence of Neurodegeneration in Spinocerebellar Ataxia Type 17 [J].
Brockmann, Kathrin ;
Reimold, Matthias ;
Globas, Christoph ;
Hauser, Till Karsten ;
Walter, Uwe ;
Machulla, Hans-Juergen ;
Rolfs, Arndt ;
Schoels, Ludger .
JOURNAL OF NUCLEAR MEDICINE, 2012, 53 (07) :1074-1080