Prognostic impact of bcl-2 expression on advanced nasopharyngeal carcinoma

被引：13

作者：

Chen, Mu-Kuan ^{[1
,2
]}

Lai, Jui-Chung ^{[1
]}

Chang, Cheng-Chuan ^{[1
]}

Chang, Julia H. ^{[3
]}

Chang, Yu-Jun ^{[4
]}

Chen, Hui-Chuan ^{[5
]}

机构：

[1] Changhua Christian Hosp, Dept Otorhinolaryngol Head & Neck Surg, Changhua, Taiwan

[2] Chang Jung Christian Univ, Inst Med Res, Tainan, Taiwan

[3] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan

[4] Changhua Christian Hosp, Epidemiol & Biostat Lab, Changhua, Taiwan

[5] Providence Univ, Dept Int Business, Taichung, Taiwan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2008年 / 30卷 / 08期

关键词：

advanced nasopharyngeal carcinoma; bcl-2; survival; prognosis; TNM stage;

D O I：

10.1002/hed.20839

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Our aim was to evaluate the prognostic impact of bcl-2 expression on patients with advanced nasopharyngeal carcinoma (NPC). Methods. One hundred five patients with advanced NPC treated with high-dose radiotherapy were included. The relationship between bcl-2 expression, TNM stage, and disease-specific survival was analyzed. Results. Within the same stage III and IV, patients with negative bcl-2 expression had better disease-free survival. The disease-free survival of patients with stage IV NPC with negative bcl-2 expression was paradoxically better than that of patients with stage III NPC with positive bcl-2 expression. In the advanced NPC, the disease-free survival of patients with stage III cancer was better than that of patients with stage IV cancer (p = 06); in contrast, patients with bcl-2-positive tumors had a worse disease-free 5-year survival (p = .02). The Cox regression model revealed that only bcl-2 expression was statistically significant (p = .03). Conclusion. In advanced staged NPC, bcl-2 expression represented an important prognostic factor. (c) 2008 Wiley Periodicals, Inc.

引用

页码：1052 / 1057

页数：6

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