Development of Cefuroxime Axetil Loaded Solid Self-Nanoemulsifying Drug Delivery System with Improved Pharmacokinetic Profile

In the current study various self-nanoemulsff3ing drug delivery systems (SNEDDS) of cefuroxime axetil (CA) were developed. Based on solubility data of CA in various components, triacetin, cremophor EL and carbitol were selected as oil, surfactant and cosurfactant, respectively. The developed CA loaded SNEDDS were evaluated for thermodynamic stability, droplet size, morphology (TEM), refractive index, viscosity, transmittance and in vitro drug release. Results showed that the mean droplet size of all self-nanoemulsifying drug delivery system were found to be in the range (23.95 to70.69 nm). All formulae also showed good optical clarity and optimum viscosity. In vitro release of cefuroxime axetil from optimized (12) self-nanoemulsifying drug delivery system formulae showed more than 84% of CA released in 10 h. The optimized self-nanoemulsifying drug delivery system was further incorporated into solid self-nanoemulsifying drug delivery system by extrusion-spheronization technique using microcrystalline cellulose and starch as a carrier. The in vivo data showed the bioavailability increased by four times in solid seff-nanoemulsifying drug delivery system compared to the other marketed preparations.