Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: Improvement of production parameters and interaction with maternally derived immunity

被引：68

作者：

Fraile, Lorenzo ^{[1
,2
]}

Grau-Roma, Llorenc ^{[1
,3
]}

Sarasola, Patxi ^{[4
]}

Sinovas, Nuria ^{[4
]}

Nofrarias, Miquel ^{[1
]}

Lopez-Jimenez, Rosa ^{[1
]}

Lopez-Soria, Sergio ^{[1
]}

Sibila, Marina ^{[1
]}

Segales, Joaquim ^{[1
,3
]}

机构：

[1] UAB IRTA, CReSA, Barcelona 08193, Spain

[2] Univ Lleida, ETSEA, Dept Anim Prod, Lleida 25198, Spain

[3] Univ Autonoma Barcelona, Dept Sanitat & Anat Anim, E-08193 Barcelona, Spain

[4] Ondax Sci, Hondarribia 20280, Spain

来源：

VACCINE | 2012年 / 30卷 / 11期

关键词：

Porcine circovirus type 2 (PCV2); Postweaning multisystemic wasting syndrome (PMWS); Inactivated vaccine; Maternal immunity interference; PORCINE CIRCOVIRUS TYPE-2; MULTISYSTEMIC WASTING SYNDROME; REAL-TIME PCR; SYNDROME PMWS; AFFECTED FARMS; PIGS; ANTIBODIES; INFECTION; RESPONSES; DIAGNOSIS;

D O I：

10.1016/j.vaccine.2012.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study describes the effects of a commercially available vaccine against Porcine circovirus type 2 (PCV2) on clinical, pathological and virological outcomes of 3-week-old piglets from two farms with a clinical history of postweaning multisystemic wasting syndrome (PMWS). The study was a controlled, double-blinded, parallel group (1:1) and randomized trial (with a negative control) involving a total of 1239 animals. The study period comprised from weaning age (time of vaccination or PBS inoculation) until the first shipment of pigs to the slaughterhouse. The vaccine product was able to reduce clinical signs, PCV2 viral load in sera and faeces, and overall mortality in nurseries and fattening units. Moreover, average daily gain was significantly higher in vaccinated versus non-vaccinated piglets during the trial period. On the other hand, it was shown that maternally derived antibodies interfered with the development of an active humoral immune response after PCV2 vaccination. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1986 / 1992

页数：7

共 34 条

[21] Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs [J].