K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa

被引：189

作者：

Kamau, Edwin ^{[1
]}

Campino, Susana ^{[2
]}

Amenga-Etego, Lucas ^{[4
]}

Drury, Eleanor ^{[2
]}

Ishengoma, Deus ^{[6
]}

Johnson, Kimberly ^{[3
]}

Mumba, Dieudonne ^{[7
]}

Kekre, Mihir ^{[2
]}

Yavo, William ^{[8
]}

Mead, Daniel ^{[2
]}

Bouyou-Akotet, Marielle ^{[9
]}

Apinjoh, Tobias ^{[10
]}

Golassa, Lemu ^{[11
,12
]}

Randrianarivelojosia, Milijaona ^{[13
]}

Andagalu, Ben ^{[1
]}

Maiga-Ascofare, Oumou ^{[14
,16
]}

Amambua-Ngwa, Alfred ^{[15
]}

Tindana, Paulina ^{[4
]}

Ghansah, Anita ^{[5
]}

MacInnis, Bronwyn ^{[2
]}

Kwiatkowski, Dominic ^{[2
,3
]}

Djimde, Abdoulaye A. ^{[2
]}

机构：

[1] KEMRI US Army Med Res Unit Kenya, Kisumu, Kenya

[2] Wellcome Trust Sanger Inst, Hinxton, England

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England

[4] Univ Ghana, Navrongo Hlth Res Ctr, Legon, Ghana

[5] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana

[6] Natl Inst Med Res, Tanga, Tanzania

[7] Univ Kinshasa, Fac Med, Ecole Sante Publ, Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[8] Natl Inst Publ Hlth, Malaria Res & Control Ctr, Abidjan, Cote Ivoire

[9] Univ Sci Sante, Fac Med, Dept Parasitol & Mycol, Libreville, Gabon

[10] Univ Buea, Buea, Cameroon

[11] Univ Addis Ababa, Aklilu Lemma Inst Pathobiol, Addis Ababa, Ethiopia

[12] Armauer Hansen Res Inst, Addis Ababa, Ethiopia

[13] Inst Pasteur Madagascar, Antananarivo, Madagascar

[14] Univ Sci Tech & Technol Bamako, Fac Pharm, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali

[15] MRC, Gambia Unit, Serekunda, Gambia

[16] Benhard Nocht Inst Trop Med, Hamburg, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 211卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

K13-propeller; artemisinin resistance; sub-Saharan Africa; ARTEMISININ RESISTANCE; MALARIA; CLEARANCE;

D O I：

10.1093/infdis/jiu608

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

引用

页码：1352 / 1355

页数：4

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