Structure and physiologic function of the low-density lipoprotein receptor

被引：253

作者：

Jeon, H ^{[1
]}

Blacklow, SC

机构：

[1] Korea Inst Sci & Technol, Div Life Sci, Seoul 136791, South Korea

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2005年 / 74卷

关键词：

receptor-mediated endocytosis; cholesterol metabolism; familial hypercholesterolemia; beta propeller; conformational change; X-ray crystallography; NMR spectroscopy;

D O I：

10.1146/annurev.biochem.74.082803.133354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The low-density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. The focus of the current review is on biochemical and structural studies of the LDLR and its ligands, emphasizing how structural features of the receptor dictate the binding of low-density lipoprotein (LDL) and beta-migrating forms of very low-density lipoprotein (beta-VLDL) particles, how the receptor releases bound ligands at low pH, and how the cytoplasmic tail of the LDLR interfaces with the endocytic machinery.

引用

页码：535 / 562

页数：28

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