Synthesis of Polysubstituted Pyrroles through a Formal [4+11 Cycloaddition/E1 cb Elimination/Aromatization Sequence of Sulfur Ylides and α,β-Unsaturated Imines

被引：38

作者：

Cheng, Bei-Yi ^{[1
]}

Wang, Ya-Ni ^{[1
]}

Li, Tian-Ren ^{[1
]}

Lu, Liang-Qiu ^{[1
]}

Xiao, Wen-Jing ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Hubei, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 23期

基金：

中国国家自然科学基金;

关键词：

4+1 ANNULATION REACTIONS; MULTICOMPONENT REACTIONS; EPOXIDATION; ACTIVATION; ALKALOIDS; CYCLOPROPANATION; HETEROCYCLES; DERIVATIVES; CATALYSIS;

D O I：

10.1021/acs.joc.7b01931

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reaction sequence comprising a formal [4 + 1] cycloaddition, an Elcb elimination, and an aromatization process is described in this work. By doing so, polysubstituted pyrroles were achieved from easily available chemicals, sulfur ylides, and alpha,beta-unsaturated imines. This protocol features mild conditions, high efficiency, and wide substrate scopes.

引用

页码：12134 / 12140

页数：7

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