Carbon nanotube fibers are compatible with mammalian cells and neurons

被引：45

作者：

Dubin, Robert A. ^{[3
]}

Callegari, Gerardo C. ^{[2
,3
]}

Kohn, Joachim

Neimark, Alexander V. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA

[2] TRI Princeton, Ctr Modeling & Characterizat Nanoporous Mat, Princeton, NJ 08542 USA

[3] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA

来源：

IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2008年 / 7卷 / 01期

关键词：

biocompatibility; carbon nanotubes; cell adhesion; neurons;

D O I：

10.1109/TNB.2008.2000144

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrate the biocompatibility of carbon nanotube fibers (CNFs) fabricated from single-wall carbon nanotubes. Produced by a particle-coagulation spinning process, CNFs are "hair-like" conductive microwires, which uniquely combine properties of porous nanostructured scaffolds, high-area electrodes, and permeable microfluidic conduits. We report that CNFs are nontoxic and support the attachment, spreading, and growth of mammalian cells and the extension of processes from neurons in vitro. Our findings suggest that CNF may be employed for an electrical interfacing of nerve cells and external devices.

引用

页码：11 / 14

页数：4

共 27 条

[1] Carbon nanotubes - the route toward applications [J].

Baughman, RH ;

Zakhidov, AA ;

de Heer, WA .

SCIENCE, 2002, 297 (5582) :787-792

[2] Continuous carbon nanotube composite fibers: properties, potential applications, and problems [J].

Dalton, AB ;

Collins, S ;

Razal, J ;

Munoz, E ;

Ebron, VH ;

Kim, BG ;

Coleman, JN ;

Ferraris, JP ;

Baughman, RH .

JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (01) :1-3

[3] Super-tough carbon-nanotube fibres -: These extraordinary composite fibres can be woven into electronic textiles. [J].

Dalton, AB ;

Collins, S ;

Muñoz, E ;

Razal, JM ;

Ebron, VH ;

Ferraris, JP ;

Coleman, JN ;

Kim, BG ;

Baughman, RH .

NATURE, 2003, 423 (6941) :703-703

[4] Engineered self-organization of neural networks using carbon nanotube clusters [J].

Gabay, T ;

Jakobs, E ;

Ben-Jacob, E ;

Hanein, Y .

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2005, 350 (2-4) :611-621

[5] Single-walled carbon nanotube polyelectrolyte multilayers and freestanding films as a biocompatible platformfor neuroprosthetic implants [J].

Gheith, MK ;

Sinani, VA ;

Wicksted, JP ;

Matts, RL ;

Kotov, NA .

ADVANCED MATERIALS, 2005, 17 (22) :2663-+

[6] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR [J].

GREENE, LA ;

TISCHLER, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) :2424-2428

[7] Chemically functionalized carbon nanotubes as substrates for neuronal growth [J].

Hu, H ;

Ni, YC ;

Montana, V ;

Haddon, RC ;

Parpura, V .

NANO LETTERS, 2004, 4 (03) :507-511

[8] Polyethyleneimine functionalized single-walled carbon nanotubes as a substrate for neuronal growth [J].

Hu, H ;

Ni, YC ;

Mandal, SK ;

Montana, V ;

Zhao, N ;

Haddon, RC ;

Parpura, V .

JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (10) :4285-4289

[9] Functionalized carbon nanotubes and nanodiamonds for engineering and biomedical applications [J].

Khabashesku, VN ;

Margrave, JL ;

Barrera, EV .

[10] Template-synthesized nanotubes for biotechnology and biomedical applications [J].

Kohli, P ;

Martin, CR .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2005, 15 (01) :49-57

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