Nickel-Catalyzed Monofluoromethylation of Aryl Boronic Acids

被引：85

作者：

Su, Yi-Ming ^{[1
]}

Feng, Guang-Shou ^{[1
]}

Wang, Zhen-Yu ^{[1
]}

Lan, Quan ^{[1
]}

Wang, Xi-Sheng ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 20期

基金：

美国国家科学基金会;

关键词：

aryl boronic acid; catalysis; monofluoromethylation; nickel; radicals; COPPER-MEDIATED DIFLUOROMETHYLATION; SECONDARY ALKYL CHLORIDES; CROSS-COUPLING REACTIONS; (2-PYRIDYL)SULFONYL GROUP; SUZUKI REACTIONS; ALPHA-ARYLATION; FLUORINATION; HALIDES; IODIDES; BROMIDES;

D O I：

10.1002/anie.201412026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aryl boronic acids can be monofluoromethylated under nickel catalysis. The utility of this method is demonstrated by the monofluoromethylation of a borylated and acyl-protected derivative of the statin drug ezetimibe. Mechanistic investigations indicate that a fluoromethyl radical is involved in the NiI/NiIII catalytic cycle. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6003 / 6007

页数：5

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