Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening

被引:72
作者
Chen, Bin [1 ]
Zhao, Yan [1 ,2 ]
Li, Shufeng [3 ]
Yang, Lanxiu [4 ]
Wang, Haiying [1 ]
Wang, Tao [2 ]
Shi, Bin [2 ]
Gai, Zhongtao [8 ]
Heng, Xueyuan [9 ]
Zhang, Chunling [7 ]
Yang, Junjie [5 ]
Zhang, Lei [1 ,6 ,7 ,8 ,9 ,10 ]
机构
[1] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China
[2] Shandong Acad Med Sci, Shandong Med & Biotechnol Ctr, Jinan 250062, Shandong, Peoples R China
[3] Shandong Univ, Qianfoshan Hosp, Dept Orthoped, Jinan 250014, Shandong, Peoples R China
[4] Guoyitang Hosp, Jinan 250000, Shandong, Peoples R China
[5] Qilu Normal Univ, Coll Life Sci, Jinan 250200, Shandong, Peoples R China
[6] Shandong Inst Food & Drug Control, Jinan 250101, Shandong, Peoples R China
[7] Qingdao Univ, Affiliated Cent Hosp, Qingdao Human Microbiome Ctr, Siliu South Rd 127, Qingdao 266042, Shandong, Peoples R China
[8] Shandong Univ, Qilu Childrens Hosp, Shandong Childrens Microbiome Ctr, Jinan 250022, Shandong, Peoples R China
[9] Lin Yi Peoples Hosp, Dept Infect Management, Dept Neurosurg, Microbiol Lab, Linyi 276003, Shandong, Peoples R China
[10] Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Chem & Environm, Beijing 100191, Peoples R China
基金
中国国家自然科学基金;
关键词
INFLAMMATION; DISEASE; DIVERSITY; SEVERITY; BACTERIA; MARKERS; HEALTH;
D O I
10.1038/s41598-018-35473-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective and non-invasive strategies for early detection and disease identification are sorely needed. Growing evidence suggests that RA has a correlation with oral microbiome and may be affected by its dynamic variations. There is already a study comparing oral microbiome in patients with RA and OA, however, it did not screen for potential biomarkers for arthritis. In this study, we assessed the oral microbiome in saliva samples from 110 RA patients, 67 OA patients and 155 healthy subjects, using 16S rRNA gene amplicon sequencing. The structure and differences in oral microbiome between RA, OA and healthy subjects were analyzed. Eight oral bacterial biomarkers were identified to differentiate RA from OA. This report provides proof of oral microbiota as an informative source for discovering non-invasive biomarkers for arthritis screening.
引用
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页数:8
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