Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer's disease

被引：23

作者：

Cui, Guo-hong ^{[1
]}

Zhu, Jing ^{[2
]}

Wang, Ya-chao ^{[2
]}

Wu, Jing ^{[1
]}

Liu, Jian-ren ^{[1
]}

Guo, Hai-dong ^{[2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai 9 Peoples Hosp, Dept Neurol, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Sch Basic Med, Dept Anat, Shanghai 201203, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Acad Integrat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2021年 / 200卷

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Exosomes; MicroRNA; Mesenchymal stem cells; Diagnosis; EXTRACELLULAR VESICLES; FUNCTIONAL RECOVERY; DELIVERY VEHICLES; MICRORNA; BIOMARKER; CELLS; ASTROCYTES; RELEASE; PROFILE; STROKE;

D O I：

10.1016/j.mad.2021.111593

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Exosomes are extracellular vesicles secreted by a variety of cells, and they participate in intercellular communication by transferring microRNA (miRNA) and other substances. Among the various internal and external factors involved in the occurrence and development of AD, exosome-derived miRNAs have become essential in the pathogenesis and treatment of AD. As nanocarriers of miRNA, exosomes are expected to become an important tool in the pathogenesis, diagnosis, and treatment of AD. This article reviews the roles of exosomal miRNAs in the pathophysiological process, diagnostic biomarkers and treatment of AD.

引用

页数：8

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