Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment

被引：88
作者：
Wadleigh, M [1 ]
Ho, V [1 ]
Momtaz, P [1 ]
Richardson, P [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Oncol,Dept Adult Oncol, Boston, MA 02115 USA
来源：
CURRENT OPINION IN HEMATOLOGY | 2003年 / 10卷 / 06期
关键词：
chemotherapy; high dose endothelial injury; risk factors; stem cell transplant; hematopoietic; veno-occlusive disease; hepatic;
D O I：
10.1097/00062752-200311000-00010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.
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收藏
页码：451 / 462
页数：12
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