Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment

被引：89
作者：
Wadleigh, M [1 ]
Ho, V [1 ]
Momtaz, P [1 ]
Richardson, P [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Oncol,Dept Adult Oncol, Boston, MA 02115 USA
来源：
CURRENT OPINION IN HEMATOLOGY | 2003年 / 10卷 / 06期
关键词：
chemotherapy; high dose endothelial injury; risk factors; stem cell transplant; hematopoietic; veno-occlusive disease; hepatic;
D O I：
10.1097/00062752-200311000-00010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.
引用
收藏
页码：451 / 462
页数：12
相关论文
共 150 条
[81]  
MCDONALD GB, 1993, MARROW TRANSPL REV, V3, P49
[82]   Antithrombin-III for the treatment of chemotherapy-induced organ dysfunction following bone marrow transplantation [J].
Morris, JD ;
Harris, RE ;
Hashmi, R ;
Sambrano, JE ;
Gruppo, RA ;
Becker, AT ;
Morris, CL .
BONE MARROW TRANSPLANTATION, 1997, 20 (10) :871-878
[83]   Marked reduction in the incidence of hepatic veno-occlusive disease after allogeneic hematopoietic stem cell transplantation with CD34+ positive selection [J].
Moscardó, F ;
Sanz, GF ;
de la Rubia, J ;
Jiménez, C ;
Saavedra, S ;
Regadera, A ;
Andreu, R ;
García, I ;
Plumé, G ;
Martínez, J ;
Martín, G ;
Jarque, I ;
Sanz, MA .
BONE MARROW TRANSPLANTATION, 2001, 27 (09) :983-987
[84]   REGIMEN-RELATED TOXICITY OF A BUSULFAN-CYCLOPHOSPHAMIDE CONDITIONING REGIMEN IN 70 PATIENTS UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION [J].
NEVILL, TJ ;
BARNETT, MJ ;
KLINGEMANN, HG ;
REECE, DE ;
SHEPHERD, JD ;
PHILLIPS, GL .
JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (07) :1224-1232
[85]  
NICOLAU C, 1993, J ULTRAS MED, V12, P437
[86]   Endothelial dysfunction after bone marrow transplantation:: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications [J].
Nürnberger, W ;
Michelmann, I ;
Burdach, S ;
Göbel, U .
ANNALS OF HEMATOLOGY, 1998, 76 (02) :61-65
[87]   Plasma thrombopoietin levels in marrow transplant patients with veno-occlusive disease of the liver [J].
Oh, H ;
Tahara, T ;
Bouvier, M ;
Farrand, A ;
McDonald, GB .
BONE MARROW TRANSPLANTATION, 1998, 22 (07) :675-679
[88]  
Ohashi K, 2000, AM J HEMATOL, V64, P32, DOI 10.1002/(SICI)1096-8652(200005)64:1<32::AID-AJH6>3.3.CO
[89]  
2-E
[90]   Low molecular weight heparin for the prevention of veno-occlusive disease of the liver in bone marrow transplantation patients [J].
Or, R ;
Nagler, A ;
Shpilberg, O ;
Elad, S ;
Naparstek, E ;
Kapelushnik, J ;
Cass, Y ;
Gillis, S ;
Chetrit, A ;
Slavin, S ;
Eldor, A .
TRANSPLANTATION, 1996, 61 (07) :1067-1071
45678910111213