Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment

被引：88

作者：

Wadleigh, M ^{[1
]}

Ho, V ^{[1
]}

Momtaz, P ^{[1
]}

Richardson, P ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Oncol,Dept Adult Oncol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2003年 / 10卷 / 06期

关键词：

chemotherapy; high dose endothelial injury; risk factors; stem cell transplant; hematopoietic; veno-occlusive disease; hepatic;

D O I：

10.1097/00062752-200311000-00010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.

引用

页码：451 / 462

页数：12

共 150 条

[1]

Abecasis M, 1999, BONE MARROW TRANSPL, V23, pS222

[2]

ALLEN JR, 1969, ARCH PATHOL, V87, P279

[3]

Alvarez R, 2000, Gastroenterol Hepatol, V23, P177

[4] TRANSFORMING GROWTH-FACTOR-BETA AS A PREDICTOR OF LIVER AND LUNG FIBROSIS AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR ADVANCED BREAST-CANCER [J].