Characterization of 3D Printed Metal-PLA Composite Scaffolds for Biomedical Applications

被引：35

作者：

Buj-Corral, Irene ^{[1
]}

Sanz-Fraile, Hector ^{[2
]}

Ulldemolins, Anna ^{[2
]}

Tejo-Otero, Aitor ^{[1
]}

Dominguez-Fernandez, Alejandro ^{[1
]}

Almendros, Isaac ^{[2
,3
]}

Otero, Jorge ^{[2
,3
]}

机构：

[1] Univ Politecn Cataluna, Sch Engn Barcelona ETSEIB, Dept Mech Engn, Av Diagonal 647, Barcelona 08028, Spain

[2] Univ Barcelona, Fac Med & Ciencies Salut, Unitat Biofis & Bioengn, Barcelona 08036, Spain

[3] CIBER Enfermedades Resp, Madrid 28029, Spain

来源：

POLYMERS | 2022年 / 14卷 / 13期

关键词：

steel-filled PLA; FFF; scaffold; grid structure; cell culture; BEHAVIORS;

D O I：

10.3390/polym14132754

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Three-dimensional printing is revolutionizing the development of scaffolds due to their rapid-prototyping characteristics. One of the most used techniques is fused filament fabrication (FFF), which is fast and compatible with a wide range of polymers, such as PolyLactic Acid (PLA). Mechanical properties of the 3D printed polymeric scaffolds are often weak for certain applications. A potential solution is the development of composite materials. In the present work, metal-PLA composites have been tested as a material for 3D printing scaffolds. Three different materials were tested: copper-filled PLA, bronze-filled PLA, and steel-filled PLA. Disk-shaped samples were printed with linear infill patterns and line spacing of 0.6, 0.7, and 0.8 mm, respectively. The porosity of the samples was measured from cross-sectional images. Biocompatibility was assessed by culturing Human Bone Marrow-Derived Mesenchymal Stromal on the surface of the printed scaffolds. The results showed that, for identical line spacing value, the highest porosity corresponded to bronze-filled material and the lowest one to steel-filled material. Steel-filled PLA polymers showed good cytocompatibility without the need to coat the material with biomolecules. Moreover, human bone marrow-derived mesenchymal stromal cells differentiated towards osteoblasts when cultured on top of the developed scaffolds. Therefore, it can be concluded that steel-filled PLA bioprinted parts are valid scaffolds for bone tissue engineering.

引用

页数：12

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