Identification of DNA basepairing via tunnel-current decay

被引：75

作者：

He, Jin ^{[1
]}

Lin, Lisha ^{[1
,2
]}

Zhang, Peirning ^{[1
]}

Lindsay, Stuart ^{[1
,2
,3
]}

机构：

[1] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[3] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 12期

关键词：

D O I：

10.1021/nl0726205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.

引用

页码：3854 / 3858

页数：5

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