Gene-Environment Interactions for Cardiovascular Disease

被引：31

作者：

Hartiala, Jaana A. ^{[1
]}

Hilser, James R. ^{[1
,2
]}

Biswas, Subarna ^{[1
,3
]}

Lusis, Aldons J. ^{[4
,5
,6
]}

Allayee, Hooman ^{[1
,2
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, 2250 Alcazar St, Los Angeles, CA 90033 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90033 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Surg, Los Angeles, CA 90033 USA

[4] UCLA, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[5] UCLA, David Geffen Sch Med, Dept Microbiol, Los Angeles, CA 90095 USA

[6] UCLA, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2021年 / 23卷 / 12期

关键词：

Cardiovascular disease; Genetics; Environmental factors; Gene-environment interactions; Genome-wide association study; CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; LOCI; SMOKING; HERITABILITY; RISK; INDIVIDUALS; MIGRATION; RESOURCE; DESIGN;

D O I：

10.1007/s11883-021-00974-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of Review We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field. Recent Findings. Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, such as physical activity, air pollution, diet, and sex. The establishment of large consortia and population-based cohorts, in combination with new computational tools and mouse genetics platforms, can potentially overcome some of the limitations that have hindered human GxE interaction studies and reveal additional association signals for CVD-related traits. Summary The identification of novel GxE interactions is likely to provide a better understanding of the pathogenesis and genetic liability of CVD, with significant implications for healthy lifestyles and therapeutic strategies.

引用

页数：9

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