Medical comorbidities in the treatment of epilepsy

被引:55
作者
Boro, A
Haut, S
机构
[1] Montefiore Med Ctr, Comprehens Epilepsy Management Ctr, Dept Neurol, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Bronx, NY 10467 USA
关键词
epilepsy; medical; comorbidity; psychiatric; reproduction; cardiovascular;
D O I
10.1016/j.yebeh.2003.07.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The treatment of epilepsy extends far beyond seizure control. Many comorbidities have a significant impact on the medical management and quality of life of patients with epilepsy. In this review, we examine interactions between epilepsy and some common medical conditions. Psychiatric disorders with a high prevalence in epilepsy include mood disorders, anxiety disorders, and psychosis. Depression is common, psychosis occurs both in direct relation to seizures and interictally, and suicide rates are increased. Changes in sexual function and reduced fertility and marriage rates are described, including a discussion of polycystic ovary syndrome, which is increased in women with epilepsy. The effects of other chronic medical comorbid conditions are reviewed, including the effects of antiepileptic medications on bone health and the impact of renal insufficiency on pharmacological therapy of epilepsy. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:S2 / S12
页数:11
相关论文
共 119 条
[51]   Altered ovarian function and cardiovascular risk factors in valproate-treated women [J].
Isojärvi, JIT ;
Tauboll, E ;
Pakarinen, AK ;
van Parys, J ;
Rättya, J ;
Harbo, HF ;
Dale, PO ;
Fauser, BCJM ;
Gjerstad, L ;
Koivunen, R ;
Knip, M ;
Tapanainen, JS .
AMERICAN JOURNAL OF MEDICINE, 2001, 111 (04) :290-296
[52]  
Jacoby A, 2002, EPILEPSY BEHAV, V3, pS10
[53]  
JACOBY A, 2001, EPILEPSIA S2, V42, pS9
[54]   Risk factors and outcome of mood disorders in epilepsy: a case-control study [J].
Jagadheesan, K ;
Garg, AK ;
Nizamie, SH .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2003, 12 (02) :121-125
[55]   Reproductive activity and offspring health of young adults with childhood-onset epilepsy: A controlled study [J].
Jalava, M ;
Sillanpaa, M .
EPILEPSIA, 1997, 38 (05) :532-540
[56]   SEXUAL DYSFUNCTION IN MALE AND FEMALE-PATIENTS WITH EPILEPSY - A STUDY OF 86 OUTPATIENTS [J].
JENSEN, P ;
JENSEN, SB ;
SORENSEN, PS ;
BJERRE, BD ;
RIZZI, DA ;
SORENSEN, AS ;
KLYSNER, R ;
BRINCH, K ;
JESPERSEN, B ;
NIELSEN, H .
ARCHIVES OF SEXUAL BEHAVIOR, 1990, 19 (01) :1-14
[57]   Carbamazepine-induced hypertension [J].
Jette, N ;
Veregin, T ;
Guberman, A .
NEUROLOGY, 2002, 59 (02) :275-276
[58]  
JOHNSON CD, 1997, P R HEALTH SCI J, P16
[59]   Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate [J].
Kaaja, E ;
Kaaja, R ;
Matila, R ;
Hiilesmaa, V .
NEUROLOGY, 2002, 58 (04) :549-553
[60]   Reexamination of interictal psychoses based on DSM IV psychosis classification and international epilepsy classification [J].
Kanemoto, K ;
Tsuji, T ;
Kawasaki, J .
EPILEPSIA, 2001, 42 (01) :98-103