Sarcopenia and Frailty: Challenges in Mainstream Nephrology Practice

被引：33

作者：

Wong, Limy ^{[1
,2
]}

Duque, Gustavo ^{[3
,4
]}

McMahon, Lawrence P. ^{[1
,2
]}

机构：

[1] Box Hill Hosp, Eastern Hlth Integrated Renal Serv, Box Hill, Vic, Australia

[2] Monash Univ, Eastern Hlth Clin Sch, Dept Renal Med, 5 Arnold St, Box Hill, Vic 3128, Australia

[3] Univ Melbourne & Western Hlth, Australian Inst Musculoskeletal Sci AIMSS, St Albans, Vic, Australia

[4] Univ Melbourne, Melbourne Med Sch, Dept Med Western Hlth, St Albans, Vic, Australia

来源：

KIDNEY INTERNATIONAL REPORTS | 2021年 / 6卷 / 10期

关键词：

chronic kidney disease; frail; frailty; muscle atrophy; muscle wasting; sarcopenia; CHRONIC KIDNEY-DISEASE; GROWTH-FACTOR-I; ASIAN WORKING GROUP; NF-KAPPA-B; PROTEIN LOSS; MULTIFREQUENCY BIOIMPEDANCE; MAINTENANCE HEMODIALYSIS; CARBOHYDRATE OXIDATION; SERUM INTERLEUKIN-6; GERIATRIC SYNDROME;

D O I：

10.1016/j.ekir.2021.05.039

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sarcopenia and frailty are prevalent in the chronic kidney disease (CKD) population. Sarcopenia is characterised by the loss of muscle mass and function, while frailty is defined as a multi-system impairment associated with increased vulnerability to stressors. There is substantial overlap between the 2 conditions, particularly with regards to physical aspects: low grip strength, gait speed and low muscle mass. Both sarcopenia and frailty have been associated with a wide range of adverse health outcomes. Although there is no recommended pharmacological treatment as yet, it is widely accepted that exercise training and nutritional supplementation are the key interventions to maintain skeletal muscle mass and strength. This review aims to present a comprehensive overview of sarcopenia and frailty in patients with CKD.

引用

页码：2554 / 2564

页数：11

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