Multi-configuration Raman spectrometer for Early Stage Diagnosis of Oral Cancer

被引：0

作者：

Maryam, Siddra ^{[1
,2
]}

Sekar, Sanathana Konugolu Venkata ^{[1
,2
]}

Nogueira, Marcelo Saito ^{[1
,2
]}

KhO, Kiang Wei ^{[1
,2
]}

Gautam, Rekha ^{[1
,2
]}

Lu, Huihui ^{[1
,2
]}

Riordain, Richeal Ni ^{[3
,4
]}

Feeley, Linda ^{[3
,5
]}

Sheahan, Patrick ^{[3
,6
]}

Burke, Ray ^{[1
,2
]}

Andersson-Engels, Stefan ^{[1
,2
]}

机构：

[1] Tyndall Natl Inst, Cork, Ireland

[2] Univ Coll Cork, Cork, Ireland

[3] Univ Coll Cork, ENTO Res Inst, Cork, Ireland

[4] Cork Univ, Dent Sch & Hosp, Cork, Ireland

[5] Cork Univ Hosp, Cork, Ireland

[6] Cork Ireland South Infirm Victoria Univ Hosp, Cork, Ireland

来源：

BIOMEDICAL VIBRATIONAL SPECTROSCOPY 2022: ADVANCES IN RESEARCH AND INDUSTRY | 2022年 / 11957卷

基金：

爱尔兰科学基金会;

关键词：

oral cancer; Raman spectroscopy; multimodal spectroscopy; SERS; saliva;

D O I：

10.1117/12.2610704

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Oral Squamous Cell carcinoma (OSCC) is one of the most common and aggressive oral malignancies. Despite all significant advances in medicine, five-year survival rate is still 40%-60%. Diagnosis in early stages is critical as it can improve the survival rate and the quality of life after treatment. This study aims to develop a strategy for diagnosing oral cancer non-invasively in the early stages and to provide better surgical guidance by differentiating healthy and tumor tissues by using Raman spectroscopy. For this purpose, a multimodal Raman system is developed to detect oral cancer biomarkers in patient's saliva specimen and to study different tissue types in oral cavity with Raman spectroscopy. The developed system is quite compact, easy to use and portable. It can be easily modified for in vivo and ex vivo analysis and can work in both reflection and transmission mode in case of ex vivo measurements. This paper compares the surface enhancement and background spectra from different plasmonic nanoparticles. Lastly, bovine serum albumin (BSA) and uric acid were used as model analytes to at physiologically relevant concentrations to test the performance of the system.

引用

页数：7

共 10 条

[1] Optimization and performance analysis of SERS-active suspended core photonic crystal fibers [J].