5,6-Dehydrokawain from Alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation

被引：23

作者：

Kumagai, Momochika ^{[1
,2
]}

Mishima, Takashi ^{[1
]}

Watanabe, Akio ^{[1
]}

Harada, Teppei ^{[1
]}

Yoshida, Izumi ^{[1
]}

Fujita, Kazuhiro ^{[1
]}

Watai, Masatoshi ^{[1
]}

Tawata, Shinkichi ^{[3
]}

Nishikawa, Keisuke ^{[2
]}

Morimoto, Yoshiki ^{[2
]}

机构：

[1] Japan Food Res Labs, Osaka, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Chem, Osaka, Japan

[3] Univ Ryukyus, Dept Biosci & Biotechnol, Fac Agr, Nishihara, Okinawa, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2016年 / 80卷 / 07期

关键词：

Alpinia zerumbet; 5; 6-dehydrokawain; MC3T3-E1; osteoblast; osteoporosis; BONE-FORMATION; ALKALINE-PHOSPHATASE; UP-REGULATION; EXPRESSION; EXTRACT; KINASE; P38; MINERALIZATION; PROLIFERATION; OSTEOPOROSIS;

D O I：

10.1080/09168451.2016.1153959

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone homeostasis is maintained by balancing bone formation and bone resorption, but an imbalance between them is associated with various bone-related diseases such as osteoporosis and rheumatoid arthritis. We found that 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK), which were isolated as promising compounds from Alpinia zerumbet rhizomes, promote differentiation of osteoblastic MC3T3-E1 cells. DK and DDK increased the alkaline phosphatase activity and matrix mineralization of MC3T3-E1 cells. DK exerts larger effects than DDK. The gene expression of runt-related transcription factor 2 and osterix, which are essential transcription factors in the early period of osteoblast differentiation, was significantly increased by DK treatment. The mRNA level of distal-less homeobox 5 was also enhanced by DK treatment, and DK activated the p38 mitogen-activated protein kinase pathway. Therefore, DK may have clinical potential for preventing osteoporosis, and could be considered as a potential anabolic therapeutic agent.

引用

页码：1425 / 1432

页数：8

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