Posaconazole salvage treatment in paediatric patients: a multicentre survey

被引：65

作者：

Lehrnbecher, T. ^{[1
]}

Attarbaschi, A. ^{[2
]}

Duerken, M. ^{[3
]}

Garbino, J. ^{[4
]}

Gruhn, B. ^{[5
]}

Kontny, U. ^{[6
]}

Luer, S. ^{[7
]}

Phillips, R. ^{[8
]}

Scholz, J. ^{[9
]}

Wagner, H. J. ^{[10
]}

Wiesel, T. ^{[11
]}

Groll, A. H. ^{[12
]}

机构：

[1] Goethe Univ Frankfurt, Childrens Hosp 3, D-60590 Frankfurt, Germany

[2] St Anna Childrens Hosp, A-1090 Vienna, Austria

[3] Childrens Hosp Mannheim, Mannheim, Germany

[4] Childrens Hosp Geneva, Geneva, Switzerland

[5] Childrens Hosp Jena, Jena, Germany

[6] Childrens Hosp Freiburg, Freiburg, Germany

[7] Childrens Hosp Bern, Bern, Switzerland

[8] Childrens Hosp Leeds, Leeds, W Yorkshire, England

[9] Childrens Hosp Frankfurt Hoechst, Frankfurt, Germany

[10] Childrens Hosp Giessen, Giessen, Germany

[11] Childrens Hosp Datteln, Datteln, Germany

[12] Childrens Hosp Munster, Munster, Germany

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2010年 / 29卷 / 08期

关键词：

INVASIVE ASPERGILLOSIS; THERAPY; FLUCONAZOLE; ZYGOMYCOSIS; PROPHYLAXIS; CASPOFUNGIN; INTOLERANT; DISEASE;

D O I：

10.1007/s10096-010-0957-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

While a paediatric dosage has not been defined, posaconazole is occasionally being used in children. We conducted a multicentre retrospective survey and identified 15 patients (median age 10 years [range 3.6-17.5]) who received posaconazole salvage therapy for proven (9 patients) or probable (6 patients) invasive fungal infections. Posaconazole was administered for a median of 32 days (range 4-262) at a median dosage of 21 mg/kg (range 4.8-33.3). None of the patients discontinued therapy due to adverse events, which were mostly mild and observed in 11 patients. Complete or partial responses were observed in 4/7 patients with zygomycosis, 3/4 patients with invasive mould infection, 1/2 patients with invasive aspergillosis and 1/2 patients with chronic disseminated candidiasis. We conclude from the data that posaconazole displays favourable safety and tolerance and may be useful for management of individual paediatric patients with invasive infections.

引用

页码：1043 / 1045

页数：3

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