Synthesis of hydroxyethyl methyl morpholinium azide (HEM Morph)N3: A highly efficient new task specific azide-based ionic liquid and its dual application as an azide source and media for synthesis of some novel aromatic O-oxime ethers-1,2,3-triazole conjugates as a potential antihistaminic agents

被引：6

作者：

Rad, Mohammad Navid Soltani ^{[1
]}

Behrouz, Somayeh ^{[1
]}

Saremi, Hossein ^{[1
]}

Mohammadtaghi-Nezhad, Javad ^{[1
]}

机构：

[1] Shiraz Univ Technol, Dept Chem, Med Chem Res Lab, Shiraz 71555313, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2020年 / 299卷

关键词：

Ionic liquid; Azide-based ionic liquid; (HEM Morph)N-3; 'Click' Huisgen cycloaddition; Aromatic O-oxime ethers-1,2,3-triazole conjugates; Antihistaminic; HETEROGENEOUS NANO-CATALYST; SILICA CUPROUS SULFATE; 3 COMPONENT SYNTHESIS; ONE-POT; CONSECUTIVE CONDENSATION; CLICK SYNTHESIS; ARYL AZIDES; C-N; SALTS; 1,2,3-TRIAZOLES;

D O I：

10.1016/j.molliq.2019.112245

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The synthesis, characterization and application of hydroxyethyl methyl morpholinium azide (HEM Morph)N-3 as a new azide-based ionic liquid (ABIL) has been described. (HEM Morph)N-3 is used as a source of azide and reaction media for three components Click Huisgen cycloaddition reaction between O-propargyl oxime ether and alkyl bromide to acquire novel aromatic O-oxime ethers-1,2,3-triazole conjugates as potential antihistaminic agents in good yields. The influence of parameters like temperature, amount of IL, type of azide-based ionic liquids and its reusability is investigated. The (HEM Morph)N-3 is proved to be an efficient, thermally stable, inexpensive and recyclable azide-based ionic liquid which can be easily synthesized and used as both azide's source and reaction media for 'Click' Huisgen cycloaddition reaction. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：10