Isolation, identification and antileukemic activity of the monoterpene indole alkaloids from Tabernaemontana salzmannii (A. DC.), Apocynaceae

被引：13

作者：

Figueiredo, Elaine R. ^{[1
]}

Vieira, Ivo J. C. ^{[2
]}

de Souza, Jucimar J. ^{[2
]}

Braz Filho, Raimundo ^{[2
]}

Mathias, Leda ^{[2
]}

Kanashiro, Milton M. ^{[3
]}

Cortes, Fernanda H. ^{[3
]}

机构：

[1] Univ Estadual Norte Fluminense, Lab Tecnol Alimentos, BR-28013602 Campos Dos Goytacazes, RJ, Brazil

[2] Univ Estadual Norte Fluminense, Lab Ciencias Quim, BR-28013602 Campos Dos Goytacazes, RJ, Brazil

[3] Univ Estadual Norte Fluminense, Lab Biol Reconhecer, BR-28013602 Campos Dos Goytacazes, RJ, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2010年 / 20卷 / 05期

关键词：

Tabernaemontana salzmannii; indole alkaloids; Apocynaceae; antileukemic activity; COMPLEX; LAETA;

D O I：

10.1590/S0102-695X2010005000019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isolation, identification and antileukemic activity of the monoterpene indole alkaloids from Tabernaemontana salzmannii (A. DC.), Apocynaceae". This work describes the isolation and structural determination of nine monoterpenic indole alkaloids from the roots bark and leaves of Tabernaemontana salzmannii. The alkaloids were identified by spectroscopic methods uni (NMR H-1, C-13, APT) and two-dimensional (H-1-H-1-COSY, H-1-H-1-NOESY, HMQC and HMBC) and mass spectra besides comparison with literature data. An in vitro screening was done with the isolated major alkaloids. Among the nine alkaloids isolated, isovoacangine and voacangine alkaloids were able to induce apoptosis cell death in human leukemic cells line THP-1.

引用

页码：675 / 681

页数：7

共 15 条

[1]

DESOUZA JJ, 2006, THESIS U ESTADUAL NO

[2] Synthesis, crystal structure, nuclease and in vitro antitumor activities of a new mononuclear copper(II) complex containing a tripodal N3O ligand [J].