Synthesis and DNA-Cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether

被引：7
作者：
Tan, Xin-Yu
Zhang, Ji
Huang, Yu
Zhang, Yu
Zhou, Li-Hong
Jiang, Ning
Lin, Hong-Hui [1 ]
Wang, Na
Xia, Chuan-Qin
Yu, Xiao-Qi
机构：
[1] Sichuan Univ, Minist Educ, Dept Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Minist Educ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Chengdu 610064, Peoples R China
[3] Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 09期
关键词：
D O I：
10.1002/cbdv.200790176
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and DNA-cleavage properties of a series of novel mononuclear Zn-II, Cu-II, and Co-II complexes 2 of a crown-ether-functionalizcd cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated. showing that 2b readily and efficiently converts supercoiled (type I) plasmid DNA to nicked (type II) DNA under physiological conditions (37 degrees, pH 7.4).
引用
收藏
页码：2190 / 2197
页数：8
相关论文
共 50 条
  • [41] Study of pH-dependent zinc(II)-carboxamide interactions by zinc(II)-carboxamide-appended cyclen complexes (cyclen=1,4,7,10-tetraazacyclododecane)
    Kimura, E
    Gotoh, T
    Aoki, S
    Shiro, M
    INORGANIC CHEMISTRY, 2002, 41 (12) : 3239 - 3248
  • [42] Artificial helix supramolecule by doubly p-xylyl bridged bis(ZnII-cyclen) (cyclen=1,4,7,10-tetraazacyclododecane)
    Ichimaru, Yoshimi
    Kato, Koichi
    Sugiura, Kirara
    Isomura, Risa
    Fujioka, Haruto
    Koike, Tohru
    Fujii-Kishida, Sayuri
    Kurihara, Masaaki
    Yamaguchi, Yoshihiro
    Jin, Wanchun
    Imai, Masanori
    Kurosaki, Hiromasa
    INORGANIC CHEMISTRY COMMUNICATIONS, 2023, 153
  • [43] SYNTHESIS AND ACID-BASE AND COMPLEX-FORMING PROPERTIES OF 1,4,7,10-TETRAKIS (DIHYDROXYPHOSPHORYLMETHYL)-1,4,7,10-TETRAAZACYCLODODECANE
    KABACHNIK, IM
    MEDVED, TY
    BELSKII, FI
    PISAREVA, SA
    BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, 1984, 33 (04): : 777 - 782
  • [44] A double-functionalized cyclen with carbamoyl and dansyl groups (cyclen=1,4,7,10-tetraazacyclododecane):: A selective fluorescent probe for Y3+ and La3+
    Aoki, S
    Kawatani, H
    Goto, T
    Kimura, E
    Shiro, M
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (06) : 1123 - 1132
  • [45] Isomerization kinetics of lanthanide(III) complexes with the pendant-arm macrocyclic ligand 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane
    Pittet, PA
    Fruh, D
    Tissieres, V
    Bunzli, JCG
    JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1997, (05): : 895 - 900
  • [46] MAGNETIC-PROPERTIES AND THERMAL TRANSFORMATIONS OF COBALT(II) RHODANIDE COMPLEXES WITH 1,4,7,10-TETRA(DIPHENYLPHOSPHINYL)-1,4,7,10-TETRAAZACYCLODODECANE
    SINYAVSKAYA, EI
    ZELENTSOV, VV
    STROESKU, AK
    KONSTANTINOVSKAYA, MA
    ZHURNAL NEORGANICHESKOI KHIMII, 1988, 33 (04): : 943 - 947
  • [47] SYNTHESIS, STRUCTURE, AND DYNAMIC PROPERTIES OF THE LANTHANUM(III) COMPLEX OF 1,4,7,10-TETRAKIS(2-CARBAMOYLETHYL)-1,4,7,10-TETRAAZACYCLODODECANE
    MORROW, JR
    AMIN, S
    LAKE, CH
    CHURCHILL, MR
    INORGANIC CHEMISTRY, 1993, 32 (21) : 4566 - 4572
  • [48] A practical synthesis of 1,4,7,10-tetraazacyclododecane, a pivotal precursor for MRI contrast agents
    Ferrari, M
    Giovenzana, GB
    Palmisano, G
    Sisti, M
    SYNTHETIC COMMUNICATIONS, 2000, 30 (01) : 15 - 21
  • [49] SYNTHESIS AND CRYSTAL STRUCTURE OF NEODYMIUM COMPLEX OF 1-METHYL-1,4,7,10-TETRAAZACYCLODODECANE
    Ping Rong WEI
    Chinese Chemical Letters, 1991, (11) : 871 - 872
  • [50] Kinetics and mechanism of aquation and base hydrolysis of the cis-[Co(cyclen)Cl2]+ cation (cyclen = 1,4,7,10-tetraazacyclododecane)
    Transition Met Chem, 3 (248):
12345