Synthesis and DNA-Cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether

被引：7
|
作者：
Tan, Xin-Yu
Zhang, Ji
Huang, Yu
Zhang, Yu
Zhou, Li-Hong
Jiang, Ning
Lin, Hong-Hui [1 ]
Wang, Na
Xia, Chuan-Qin
Yu, Xiao-Qi
机构：
[1] Sichuan Univ, Minist Educ, Dept Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Minist Educ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Chengdu 610064, Peoples R China
[3] Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 09期
关键词：
D O I：
10.1002/cbdv.200790176
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and DNA-cleavage properties of a series of novel mononuclear Zn-II, Cu-II, and Co-II complexes 2 of a crown-ether-functionalizcd cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated. showing that 2b readily and efficiently converts supercoiled (type I) plasmid DNA to nicked (type II) DNA under physiological conditions (37 degrees, pH 7.4).
引用
收藏
页码：2190 / 2197
页数：8
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