Nanotechnology-based drug delivery for central nervous system disorders

被引：90
作者：
Nguyen, Thuy Trang [1 ]
Nguyen, Thi Thuy Dung [2 ]
Vo, Tuong Kha [3 ]
Tran, Nguyen-Minh-An [4 ]
Nguyen, Minh Kim [5 ]
Van Vo, Toi [6 ,9 ]
Van Vo, Giau [7 ,8 ,9 ]
机构：
[1] Ho Chi Minh City Univ Technol HUTECH, Fac Pharm, Ho Chi Minh City 700000, Vietnam
[2] Nguyen Tat Thanh Univ, Fac Environm & Food Engn, Ho Chi Minh City 700000, Vietnam
[3] Minist Culture Sports & Tourism, Viet Nam Sports Hosp, Hanoi 100000, Vietnam
[4] Ind Univ Ho Chi Minh City, Fac Chem Engn, Ho Chi Minh City 71420, Vietnam
[5] Univ Technol & Educ, Univ Danang, Dept Chem Engn Environm, 48 Cao Thang St, Danang City 550000, Vietnam
[6] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Int Univ, Sch Biomed Engn, Ho Chi Minh City 700000, Vietnam
[7] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Sch Med, Dept Biomed Engn, Ho Chi Minh City 700000, Vietnam
[8] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Sch Med, Res Ctr Genet & Reprod Hlth, Ho Chi Minh City 700000, Vietnam
[9] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Ho Chi Minh City 700000, Vietnam
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 143卷
关键词：
CNS; Nanoparticles; Molecular targets; Oxidative stress; Nanomedicine; BLOOD-BRAIN-BARRIER; TISSUE-PLASMINOGEN-ACTIVATOR; LOADED CHITOSAN NANOPARTICLES; TARGETED LIPOSOMAL DOXORUBICIN; INTERLEUKIN-4; IL-4; RECEPTORS; ALZHEIMERS-DISEASE; AMYLOID-BETA; IN-VITRO; IMPROVE TREATMENT; BINDING-AFFINITY;
D O I：
10.1016/j.biopha.2021.112117
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Drug delivery to central nervous system (CNS) diseases is very challenging since the presence of the innate blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier that impede drug delivery. Among new strategies to overcome these limitations and successfully deliver drugs to the CNS, nanotechnology-based drug delivery platform, offers potential therapeutic approach for the treatment of some common neurological disorders like Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease. This review aimed to highlight advances in research on the development of nano-based therapeutics for their implications in therapy of CNS disorders. The challenges during clinical translation of nanomedicine from bench to bed side is also discussed.
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收藏
页数：13
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