Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice

被引：30
作者：
Kharbangar, A [1 ]
Khynriam, D [1 ]
Prasad, SB [1 ]
机构：
[1] NE Hill Univ, Dept Zool, Cell & Tumor Biol Lab, Shillong 793022, Meghalaya, India
来源：
CELL BIOLOGY AND TOXICOLOGY | 2000年 / 16卷 / 06期
关键词：
cisplatin; glutathione; lipid peroxidation; mitochondria; protein; succinate dehydrogenase;
D O I：
10.1023/A:1007648427024
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cisplatin treatment of tumor-bearing mice resulted a significant decrease of protein in the tissues studied (liver, kidney, and Dalton lymphoma) and also in their mitochondrial fractions. As compared to respective tissues, the protein decrease was noted to be more conspicuous in their mitochondrial fractions. Similarly, mitochondrial glutathione also decreased significantly in the tissues. However, succinate dehydrogenase activity was selectively decreased in the kidney and Dalton lymphoma cells, whereas in liver it remained almost unchanged. An increase in serum urea concentration and kidney mitochondrial lipid peroxidation was also observed after cisplatin treatment. It is suggested that the cisplatin-induced biochemical changes in mitochondria involving mitochondrial protein, glutathione, and succinate dehydrogenase could be the important potent cellular sites contributing to toxicity/cytotoxicity after cisplatin treatment.
引用
收藏
页码：363 / 373
页数：11
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