Synthesis of the endothiopeptide BOC-Trp-Ile-Ala-Aib-Ile-Valψ[CSNH]Aib-Leu-Aib-Pro-OMe by a variation of the 'azirine/oxazolone method'

被引：43

作者：

Lehmann, J ^{[1
]}

Linden, A ^{[1
]}

Heimgartner, H ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

TETRAHEDRON | 1998年 / 54卷 / 30期

关键词：

D O I：

10.1016/S0040-4020(98)00506-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the decaendothiopeptide BOC-Trp-Ile-Ala-Aib-Ile-Val Psi[CSNH]Aib-Leu-Aib-Pro-OMe is described. The introduction of the thioamide group next to the bulky Aib occurred via a variation of the 'azirine/oxazolone method' without epimerisation. The structure of the decaendothiopeptide was etablished by single-crystal X-ray crystallography, thereby two types of helices could be observed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8721 / 8736

页数：16

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