Ocular Perfusion Pressure in 7-and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Purpose: The purpose of this study was to report the distribution of mean ocular perfu-sion pressure (MOPP) and its associated factors in Chinese children.Methods: We enrolled 3048 grade 1 students and 2258 grade 7 students of the Anyang Childhood Eye Study in central China. Systolic and diastolic blood pressure (SBP and DBP) were recorded with a digital automatic sphygmomanometer. Intraocular pressure (IOP) was assessed by a non-contact tonometer. MOPP was calculated as 2/3 x (DBP + 1/3[SBP - DBP]) -IOP. Risk factors for myopia were obtained through a questionnaire survey.Results: The MOPP was 33.83 +/- 6.37 mm Hg (mean +/- SD) in grade 1, which was lower than 36.99 +/- 6.80 mm Hg in grade 7 (P < 0.001). Compared with myopic eyes, non-myopic eyes had higher MOPP in grade 7 (37.72 +/- 6.72 mm Hg versus 36.58 +/- 6.57 mm Hg, P < 0.001) and in grade 1 (33.88 +/- 6.29 mm Hg versus 33.12 +/- 7.03 mm Hg, P = 0.12). Multivariable analysis showed that higher MOPP was associated with less myopia (P < 0.001), higher body mass index (BMI; P < 0.001), thinner central corneal thickness (P < 0.001), less time on near work (P < 0.001), and more time on sleeping (P = 0.04). Conclusions: MOPP was higher in children of older age, with higher BMI, less time on near work, and more time on sleeping, and was higher in eyes with less myopia.Translational Relevance: We found that MOPP might be an indicator for the detection of myopia development.