Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

被引：117

作者：

Jelenkovic, Aline ^{[1
,2
]}

Sund, Reijo ^{[1
]}

Hur, Yoon-Mi ^{[3
]}

Yokoyama, Yoshie ^{[4
]}

Hjelmborg, Jacob V. B. ^{[5
]}

Moller, Soren ^{[5
]}

Honda, Chika ^{[6
]}

Magnusson, Patrik K. E. ^{[7
]}

Pedersen, Nancy L. ^{[7
]}

Ooki, Syuichi ^{[8
]}

Aaltonen, Sari ^{[1
,9
]}

Stazi, Maria A. ^{[10
]}

Fagnani, Corrado ^{[10
]}

D'Ippolito, Cristina ^{[10
]}

Freitas, Duarte L. ^{[11
]}

Maia, Jose Antonio ^{[12
]}

Ji, Fuling ^{[13
]}

Ning, Feng ^{[13
]}

Pang, Zengchang ^{[13
]}

Rebato, Esther ^{[2
]}

Busjahn, Andreas ^{[14
]}

Kandler, Christian ^{[15
]}

Saudino, Kimberly J. ^{[16
]}

Jang, Kerry L. ^{[17
]}

Cozen, Wendy ^{[18
,19
]}

Hwang, Amie E. ^{[18
]}

Mack, Thomas M. ^{[18
,19
]}

Gao, Wenjing ^{[20
]}

Yu, Canqing ^{[20
]}

Li, Liming ^{[20
]}

Corley, Robin P. ^{[21
]}

Huibregtse, Brooke M. ^{[21
]}

Derom, Catherine A. ^{[22
,23
]}

Vlietinck, Robert F. ^{[22
]}

Loos, Ruth J. F. ^{[24
]}

Heikkila, Kauko ^{[9
]}

Wardle, Jane ^{[25
]}

Llewellyn, Clare H. ^{[25
]}

Fisher, Abigail ^{[25
]}

McAdams, Tom A. ^{[26
]}

Eley, Thalia C. ^{[26
]}

Gregory, Alice M. ^{[27
]}

He, Mingguang ^{[28
,29
]}

Ding, Xiaohu ^{[28
]}

Bjerregaard-Andersen, Morten ^{[30
,31
,32
]}

Beck-Nielsen, Henning ^{[32
]}

Sodemann, Morten ^{[33
]}

Tarnoki, Adam D. ^{[34
,35
]}

Tarnoki, David L. ^{[34
,35
]}

Knafo-Noam, Ariel ^{[36
]}

机构：

[1] Univ Helsinki, Dept Social Res, Helsinki, Finland

[2] Univ Basque Country, UPV EHU, Dept Genet Phys Anthropol & Anim Physiol, Leioa, Spain

[3] Mokpo Natl Univ, Dept Educ, Jeonnam, South Korea

[4] Osaka City Univ, Dept Publ Hlth Nursing, Osaka 558, Japan

[5] Univ Southern Denmark, Dept Publ Hlth Epidemiol Biostat & Biodemog, Danish Twin Registry, Odense, Denmark

[6] Osaka Univ, Grad Sch Med, Osaka, Japan

[7] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[8] Ishikawa Prefectural Nursing Univ, Dept Hlth Sci, Kahoku, Ishikawa, Japan

[9] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[10] Natl Ctr Epidemiol Surveillance & Hlth Promot, Ist Super Sanita, Rome, Italy

[11] Univ Madeira, Dept Phys Educ & Sport, Funchal, Portugal

[12] Univ Porto, Fac Sport, CIFI2D, Rua Campo Alegre 823, P-4100 Oporto, Portugal

[13] Qingdao Ctr Dis Control & Prevent, Dept Noncommunicable Dis Prevent, Qingdao, Peoples R China

[14] HlthTwiSt GmbH, Berlin, Germany

[15] Univ Bielefeld, Dept Psychol, D-33615 Bielefeld, Germany

[16] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA

[17] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[18] Univ So Calif, Dept Prevent Med, Keck Sch Med USC, Los Angeles, CA 90089 USA

[19] USC Norris Comprehens Canc Ctr, Los Angeles, CA USA

[20] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

[21] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

[22] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium

[23] Ghent Univ Hosp, Dept Obstet & Gynaecol, Ghent, Belgium

[24] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, Charles Bronfman Inst Personal Med, New York, NY 10029 USA

[25] UCL, Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London, England

[26] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England

[27] Univ London, Dept Psychol, London, England

[28] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China

[29] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic, Australia

[30] INDEPTH Network, Bandim Hlth Project, Bissau, Guinea Bissau

[31] Statens Serum Inst, Res Ctr Vitamins & Vaccines, DK-2300 Copenhagen, Denmark

[32] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark

[33] Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark

[34] Semmelweis Univ, Dept Radiat Oncol, H-1085 Budapest, Hungary

[35] Hungarian Twin Registry, Budapest, Hungary

[36] Hebrew Univ Jerusalem, Jerusalem, Israel

[37] Hebrew Univ Jerusalem, Sch Med, Hadassah Hosp Obstet, Jerusalem, Israel

[38] Hebrew Univ Jerusalem, Sch Med, Dept Gynecol, Jerusalem, Israel

[39] Michigan State Univ, E Lansing, MI 48824 USA

[40] Virginia Commonwealth Univ, Dept Human Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA

[41] Virginia Commonwealth Univ, Dept Human Mol Genet, Psychiat & Massey Canc Ctr, Richmond, VA USA

[42] Univ Minnesota, Dept Psychol, Minneapolis, MN USA

[43] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA

[44] Natl Acad Sci, Inst Med, Washington, DC 20418 USA

[45] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[46] Royal Childrens Hosp, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic 3052, Australia

[47] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[48] Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada

[49] Univ Laval, Ecole Psychol, Quebec City, PQ, Canada

[50] Tomsk State Univ, Inst Genet Neurobiol & Social Fdn Child Dev, Tomsk, Russia

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院; 日本学术振兴会; 芬兰科学院; 新加坡国家研究基金会; 欧洲研究理事会; 英国生物技术与生命科学研究理事会; 英国经济与社会研究理事会; 中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; GROWTH; HERITABILITY; CHILDHOOD; WEIGHT; AGE; DISEASES; STATURE; BIRTH;

D O I：

10.1038/srep28496

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

引用

页数：13

共 47 条

[31] Variance components models for gene-environment interaction in twin analysis
Purcell, S
[J]. TWIN RESEARCH, 2002, 5 (06): : 554 - 571
[32] Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome
Rao, E
Weiss, B
Fukami, M
Rump, A
Niesler, B
Mertz, A
Muroya, K
Binder, G
Kirsch, S
Winkelmann, M
Nordsiek, G
Heinrich, U
Breuning, MH
Ranke, MB
Rosenthal, A
Ogata, T
Rappold, GA
[J]. NATURE GENETICS, 1997, 16 (01) : 54 - 63
[33] GROWTH DURING PUBERTY IN THE XYY BOY
RATCLIFFE, SG
PAN, H
MCKIE, M
[J]. ANNALS OF HUMAN BIOLOGY, 1992, 19 (06) : 579 - 587
[34] Population genetic differentiation of height and body mass index across Europe
Robinson, Matthew R.
Hemani, Gibran
Medina-Gomez, Carolina
Mezzavilla, Massimo
Esko-, Tonu
Shakhbazov, Konstantin
Powell, Joseph E.
Vinkhuyzen, Anna
Berndt, Sonja I.
Gustafsson, Stefan
Justice, Anne E.
Kahali, Bratati
Locke, Adam E.
Pers, Tune H.
Vedantam, Sailaja
Wood, Andrew R.
van Rheenen, Wouter
Andreassen, Ole A.
Gasparini, Paolo
Metspalu, Andres
van den Berg, Leonard H.
Veldink, Jan H.
Rivadeneira, Fernando
Werge, Thomas M.
Abecasis, Goncalo R.
Boomsma, Dorret I.
Chasman, Daniel I.
de Geus, Eco J. C.
Frayling, Timothy M.
Hirschhorn, Joel N.
Hottenga, Jouke Jan
Ingelsson, Erik
Loos, Ruth J. F.
Magnusson, Patrik K. E.
Martin, Nicholas G.
Montgomery, Grant W.
North, Kari E.
Pedersen, Nancy L.
Spector, Timothy D.
Speliotes, Elizabeth K.
Goddard, Michael E.
Yang, Jian
Visscher, Peter M.
[J]. NATURE GENETICS, 2015, 47 (11) : 1357 - +
[35] Heritability of adult body height:: A comparative study of twin cohorts in eight countries
Silventoinen, K
Sammalisto, S
Perola, M
Boomsma, DI
Cornes, BK
Davis, C
Dunkel, L
de Lange, M
Harris, JR
Hjelmborg, JVB
Luciano, M
Martin, NG
Mortensen, J
Nisticò, L
Pedersen, NL
Skytthe, A
Spector, TD
Stazi, MA
Willemsen, G
Kaprio, J
[J]. TWIN RESEARCH, 2003, 6 (05): : 399 - 408
[36] Determinants of variation in adult body height
Silventoinen, K
[J]. JOURNAL OF BIOSOCIAL SCIENCE, 2003, 35 (02) : 263 - 285
[37] Silventoinen K, 2001, Twin Res, V4, P25, DOI 10.1375/twin.4.1.25
[38] Genetic regulation of growth from birth to 18 years of age:: The Swedish young male twins study
Silventoinen, Karri
Pietilainen, Kirsi H.
Tynelius, Per
Sorensen, Thorkild I. A.
Kaprio, Jaakko
Rasmussen, Finn
[J]. AMERICAN JOURNAL OF HUMAN BIOLOGY, 2008, 20 (03) : 292 - 298
[39] Genetic regulation of growth in height and weight from 3 to 12 years of age: A longitudinal study of Dutch twin children
Silventoinen, Karri
Bartels, Meike
Posthuma, Danielle
Burk, G. Frederiek Estourgie-van
Willemsen, Gonneke
van Beijsterveldt, Toos C. E. M.
Boomsma, Dorret I.
[J]. TWIN RESEARCH AND HUMAN GENETICS, 2007, 10 (02) : 354 - 363
[40] The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
Silventoinen, Karri
Jelenkovic, Aline
Sund, Reijo
Honda, Chika
Aaltonen, Sari
Yokoyama, Yoshie
Tarnoki, Adam D.
Tarnoki, David L.
Ning, Feng
Ji, Fuling
Pang, Zengchang
Ordonana, Juan R.
Sanchez-Romera, Juan F.
Colodro-Conde, Lucia
Burt, S. Alexandra
Klump, Kelly L.
Medland, Sarah E.
Montgomery, Grant W.
Kandler, Christian
McAdams, Tom A.
Eley, Thalia C.
Gregory, Alice M.
Saudino, Kimberly J.
Dubois, Lise
Boivin, Michel
Haworth, Claire M. A.
Plomin, Robert
Oncel, Sevgi Y.
Aliev, Fazil
Stazi, Maria A.
Fagnani, Corrado
D'Ippolito, Cristina
Craig, Jeffrey M.
Saffery, Richard
Siribaddana, Sisira H.
Hotopf, Matthew
Sumathipala, Athula
Spector, Timothy
Mangino, Massimo
Lachance, Genevieve
Gatz, Margaret
Butler, David A.
Bayasgalan, Gombojav
Narandalai, Danshiitsoodol
Freitas, Duarte L.
Maia, Jose Antonio
Harden, K. Paige
Tucker-Drob, Elliot M.
Christensen, Kaare
Skytthe, Axel
[J]. TWIN RESEARCH AND HUMAN GENETICS, 2015, 18 (04) : 348 - 360

← 1 2 3 4 5 →