Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

被引：59

作者：

Zugna, Daniela ^{[1
]}

Galassi, Claudia ^{[1
]}

Annesi-Maesano, Isabella ^{[2
,3
]}

Baiz, Nour ^{[2
,3
]}

Barros, Henrique ^{[4
,5
]}

Basterrechea, Mikel ^{[6
]}

Correia, Sofia ^{[4
,5
]}

Duijts, Liesbeth ^{[7
,8
]}

Esplugues, Ana ^{[9
,10
,11
]}

Fantini, Maria Pia ^{[12
]}

Forastiere, Francesco ^{[13
]}

Gascon, Mireia ^{[14
,15
,16
]}

Gori, Davide ^{[12
]}

Inskip, Hazel ^{[17
]}

Larsen, Pernille S. ^{[18
]}

Mommers, Monique ^{[19
]}

Andersen, Anne-Marie Nybo ^{[18
]}

Penders, John ^{[19
,20
]}

Petersen, Maria S. ^{[21
]}

Pike, Katharine ^{[22
]}

Porta, Daniela ^{[13
]}

Sonnenschein-van der Voort, Agnes ^{[7
,8
]}

Steuerwald, Ulrike

Sunyer, Jordi ^{[14
,15
,16
]}

Torrent, Maties ^{[23
]}

Vrijheid, Martine ^{[14
,15
,16
]}

Richiardil, Lorenzo ^{[1
]}

Rusconi, Franca ^{[24
]}

机构：

[1] Univ Turin, Citta Salute & Sci Univ Hosp, Dept Med Sci, Canc Epidemiol Unit,CPO Piedmt, I-10124 Turin, Italy

[2] INSERM, U707, Epidemiol Allerg & Resp Dis EPAR Dept, Paris, France

[3] UPMC, Univ Paris 04, EPAR UMR S 707, Med Sch St Antoine, Paris, France

[4] Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4100 Porto, Portugal

[5] Inst Publ Hlth, EPIUnit, Porto, Portugal

[6] CIBERESP, Subdirecc Salud Publ Gipuzkoa, Dept Sanidad Gobierno Vasco, Biodonostia,Donostia Ospitalea, Donostia San Sebastian, Basque Country, Spain

[7] Erasmus MC, Dept Epidemiol, Generat R Study, Rotterdam, Netherlands

[8] Erasmus MC, Dept Pediat, Div Resp Med & Neonatol, Rotterdam, Netherlands

[9] Univ Valencia, E-46003 Valencia, Spain

[10] CIBERESP, Valencia, Spain

[11] FISABIO, Fdn Promot Hlth & Biomed Res Valencian Reg, Valencia, Spain

[12] Univ Bologna Alma Mater Studiorum, Dept Biomed & Neuromotor Sci, Bologna, Italy

[13] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[14] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[15] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain

[16] Spanish Consortium Res Epidemiol CIBERESP, Barcelona, Spain

[17] Univ Southampton, Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[18] Univ Copenhagen, Dept Publ Hlth, Sect Social Med, Copenhagen, Denmark

[19] Maastricht Univ Med Ctr, CAPHRI Sch Publ Hlth & Primary Care, Dept Epidemiol, Maastricht, Netherlands

[20] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Med Microbiol, NL-6200 MD Maastricht, Netherlands

[21] Faroese Hosp Syst, Dept Occupat Med & Publ Hlth, Torshavn, Faroe Islands, Denmark

[22] Univ Southampton, Fac Med, Clin & Expt Sci Acad Unit, Southampton SO9 5NH, Hants, England

[23] IB SALUT, Area Salud Menorca, Menorca, Spain

[24] Meyer Childrens Univ Hosp, Epidemiol Unit, Florence, Italy

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2015年 / 44卷 / 01期

关键词：

Pregnancy induced hypertension; Pre-eclampsia; Gestational diabetes; Overweight; Obesity; GESTATIONAL WEIGHT-GAIN; PREPREGNANCY OBESITY; PRESCHOOL-CHILDREN; ASTHMA SYMPTOMS; RISK; DISEASE; GROWTH; SIZE;

D O I：

10.1093/ije/dyu260

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient. Methods: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index >= 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model. Results: The study included 85 509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P = 0.027). Conclusions: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

引用

页码：199 / 208

页数：10

共 36 条

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