A novel Zinc-catalyzed Cadiot-Chodkiewicz cross-coupling reaction of terminal alkynes with 1-bromoalkynes in ethanol solvent

被引：28

作者：

Krishnan, K. Keerthi ^{[1
]}

Ujwaldev, S. M. ^{[1
]}

Thankachan, Amrutha P. ^{[1
]}

Harry, Nissy Ann ^{[1
]}

Anilkumar, Gopinathan ^{[1
,2
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India

[2] Mahatma Gandhi Univ, AMMRC, PD Hills PO, Kottayam 686560, Kerala, India

来源：

MOLECULAR CATALYSIS | 2017年 / 440卷

关键词：

Zinc catalysis; C-C coupling; Cadiot-Chodkiewicz reaction; 1,3-diynes; Cross-coupling; UNSYMMETRICAL 1,3-DIYNES; SELECTIVE SYNTHESIS; CONJUGATED DIYNES; COPPER CATALYSIS; REAGENTS;

D O I：

10.1016/j.mcat.2017.07.021

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel Et2Zn/L-proline catalyzed synthesis of symmetrical as well as unsymmetrical buta-1,3-diynes by the cross-coupling of terminal alkynes with 1-bromo alkynes in ethanol solvent was developed in good yields under simple and mild reaction conditions. The use of relatively non toxic and ecofriendly nature of Zn, inexpensive amino acid ligand L-proline and environmentally benign solvent EtOH make this protocol a better alternative for the synthesis of 1,3-diynes. The scope and limitations of this protocol were investigated. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：140 / 147

页数：8

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