Synthesis of monodispersed pH-sensitive Ni0.5Zn0.5Fe2O4 magnetic nanoparticles and the potential medical application of adsorption for bovine serum album

We synthesized Ni0.5Zn0.5Fe2O4 magnetic nanoparticles (MNPs) by co-precipitation method and performed its adsorption of bovine serum albumin V(BSA (V)). The Ni0.5Zn0.5Fe2O4 MNPs in nitrogen atmosphere annealed at 400, 500, 600, 700 and 800 degrees C, respectively. X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer(VSM) were used to characterize the resulting powders of the structure and properties. XRD results show that the Ni0.5Zn0.5Fe2O4 powder is a typical single-phase cubic spinel structure, and has no impurity phases. TEM results show that the Ni0.5Zn0.5Fe2O4 crystalline size is approximately 30-50 nm, which is similar with the XRD estimate results. The magnetic measurements show that Ni0.5Zn0.5Fe2O4 samples, super paramagnetic material, have high saturation magnetization and small coercivity properties. Moreover, We adopted ultraviolet spectrophotometer to analysis adsorption of BSA(V) on the Ni0.5Zn0.5Fe2O4 MNPs at room temperature, which show that annealed temperatures, pH, and stirring time can affect BSA(V) adsorption on the Ni0.5Zn0.5Fe2O4 MNPs. Most importantly, when ultrasonic stirring 2 hours in the liquor BSA(V) at pH = 7.0, the Ni0.5Zn0.5Fe2O4 samples annealed at 600 degrees C has a highest value of 39.81 mgg(-1). From above these results, Ni0.5Zn0.5Fe2O4 MNPs reveals a great adsorbing ability for BSA(V) that probable are a potential BSA-carrier candidate.