Effect of ionic liquids on human colon carcinoma HT-29 and CaCo-2 cell lines

被引：126

作者：

Frade, Raquel F. M.

Matias, Ana

Branco, Luis C.

Afonso, Carlos A. M.

Duarte, Catarina M. M.

机构：

[1] IBET, ITQ, Nutraceut & Delivery Lab, P-2781 Oeiras, Portugal

[2] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829 Caparica, Portugal

[3] Inst Super Tecn, Ctr Quim Fis Mol, P-1049 Lisbon, Portugal

来源：

GREEN CHEMISTRY | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1039/b617526k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The toxicity of ionic liquids, involving different classes of cations and different types of anions, was evaluated by a colorimetric assay with 3-(4,5-dimethylthiazolyl- 2)-2,5-diphenyltetrazolium bromide (MTT) in two colon carcinoma HT-29 and CaCo-2 cell lines. Confluent CaCo-2 cells can undergo spontaneously an enterocytic differentiation and represent a good in vitro model of normal human intestinal epithelium. Ionic liquids are highly promising due to their low vapour pressures, however, toxicity evaluation of these ionic liquids is of great importance to assess the risk of these ionic liquids to humans and the environment.

引用

页码：873 / 877

页数：5

共 19 条

[1]

Branco LC, 2002, CHEM-EUR J, V8, P3671, DOI 10.1002/1521-3765(20020816)8:16<3671::AID-CHEM3671>3.0.CO

[2]

2-9

[3]

DORSEY WC, 2000, INT J ENV RES PUBLIC, V1, P100

[4] Ionic liquid (molten salt) phase organometallic catalysis [J].