Synthesis and biological activity of some unsaturated 6-azauracil acyclonucleosides

被引：25

作者：

Kabbaj, Y

Lazrek, HB ^{[1
]}

Barascut, JL

Imbach, JL

机构：

[1] Fac Sci Semlalia, Bioorgan Chem Lab, Marrakech, Morocco

[2] Univ Montpellier 2, CNRS, UMR 5625, Lab Chim Organ Biomol Synth, Montpellier, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 03期

关键词：

D O I：

10.1081/NCN-200055695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A useful route is described for obtaining Z and E unsaturated alkylating agents 3 and 4. Coupling 6-azauracits 5 and 6 with unsaturated alkylating agent followed by the deprolection with H' resin gave acyclonucleosides 11-14 in good overall yields. Unsaturated acyclonucleosides phosphonates 19 and 20 were prepared using potassium carbonate as base and 4-bromobut-2-enyl diethyl phosphonate 16 as the alkylating agent. The introduction of a propargyl group at the N-3 position of acyclonucleasides 7, 8, 17, 18, 19, and 20 was achieved using potassium carbonate in DMF.

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页码：161 / 172

页数：12

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