Numerous 40Ar/39Ar experiments on sanidine and biotite from 22 ash beds and 3 volcaniclastic sand beds from the Greater Green River, Piceance Creek, and Uinta Basins of Wyoming, Colorado, and Utah constrain similar to 8 m.y. of the Eocene Epoch. Multiple analyses were conducted per sample using laser fusion and incremental heating techniques to differentiate inheritance, 40Ar loss, and 39Ar recoil. When considered in conjunction with existing radioisotopic ages and lithostratigraphy, biostratigraphy, and magnetostratigraphy, these new age determinations facilitate temporal correlation of linked Eocene lake basins in the Laramide Rocky Mountain region at a significantly increased level of precision. To compare our results to the geomagnetic polarity time scale and the regional volcanic record, the ages of Eocene magnetic anomalies C24 through C20 were recalibrated using seven 40Ar/39Ar ages. Overall, the ages obtained for this study are consistent with the isochroneity of North American land-mammal ages throughout the study area, and provide precise radioisotopic constraints on several important biostratigraphic boundaries. Numerous 40Ar/39Ar experiments on sanidine and biotite from 22 ash beds and 3 volcaniclastic sand beds from the Greater Green River, Piceance Creek, and Uinta Basins of Wyoming, Colorado, and Utah constrain similar to 8 m.y. of the Eocene Epoch. Multiple analyses were conducted per sample using laser fusion and incremental heating techniques to differentiate inheritance, 40Ar loss, and 39Ar recoil. When considered in conjunction with existing radioisotopic ages and lithostratigraphy, biostratigraphy, and magnetostratigraphy, these new age determinations facilitate temporal correlation of linked Eocene lake basins in the Laramide Rocky Mountain region at a significantly increased level of precision. To compare our results to the geomagnetic polarity time scale and the regional volcanic record, the ages of Eocene magnetic anomalies C24 through C20 were recalibrated using seven 40Ar/39Ar ages. Overall, the ages obtained for this study are consistent with the isochroneity of North American land-mammal ages throughout the study area, and provide precise radioisotopic constraints on several important biostratigraphic boundaries. Numerous 40Ar/39Ar experiments on sanidine and biotite from 22 ash beds and 3 volcaniclastic sand beds from the Greater Green River, Piceance Creek, and Uinta Basins of Wyoming, Colorado, and Utah constrain similar to 8 m.y. of the Eocene Epoch. Multiple analyses were conducted per sample using laser fusion and incremental heating techniques to differentiate inheritance, 40Ar loss, and 39Ar recoil. When considered in conjunction with existing radioisotopic ages and lithostratigraphy, biostratigraphy, and magnetostratigraphy, these new age determinations facilitate temporal correlation of linked Eocene lake basins in the Laramide Rocky Mountain region at a significantly increased level of precision. To compare our results to the geomagnetic polarity time scale and the regional volcanic record, the ages of Eocene magnetic anomalies C24 through C20 were recalibrated using seven 40Ar/39Ar ages. Overall, the ages obtained for this study are consistent with the isochroneity of North American land-mammal ages throughout the study area, and provide precise radioisotopic constraints on several important biostratigraphic boundaries.