The Multifaceted Role of Serotonin in Intestinal Homeostasis

被引：58

作者：

Koopman, Nienke ^{[1
]}

Katsavelis, Drosos ^{[1
]}

Hove, Anne S. ten ^{[2
]}

Brul, Stanley ^{[1
]}

Jonge, Wouter J. de ^{[2
]}

Seppen, Jurgen ^{[2
]}

机构：

[1] Univ Amsterdam, Swammerdam Inst Life Sci SILS, NL-1098XH Amsterdam, Netherlands

[2] Amsterdam Univ Med Ctr, Tytgat Inst Liver & Intestinal Res, Locat AMC, NL-1105BK Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

inflammatory bowel disease; intestine; tryptophan; microbiome; INFLAMMATORY-BOWEL-DISEASE; 5-HT3 RECEPTOR ANTAGONIST; GUT MICROBIOTA DEPLETION; ENTERIC NERVOUS-SYSTEM; ACID-INDUCED COLITIS; CHAIN FATTY-ACIDS; NEURONAL SEROTONIN; REUPTAKE TRANSPORTER; DENDRITIC CELLS; MUCOSAL SEROTONIN;

D O I：

10.3390/ijms22179487

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.

引用

页数：23

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