The Multifaceted Role of Serotonin in Intestinal Homeostasis

被引:58
作者
Koopman, Nienke [1 ]
Katsavelis, Drosos [1 ]
Hove, Anne S. ten [2 ]
Brul, Stanley [1 ]
Jonge, Wouter J. de [2 ]
Seppen, Jurgen [2 ]
机构
[1] Univ Amsterdam, Swammerdam Inst Life Sci SILS, NL-1098XH Amsterdam, Netherlands
[2] Amsterdam Univ Med Ctr, Tytgat Inst Liver & Intestinal Res, Locat AMC, NL-1105BK Amsterdam, Netherlands
关键词
inflammatory bowel disease; intestine; tryptophan; microbiome; INFLAMMATORY-BOWEL-DISEASE; 5-HT3 RECEPTOR ANTAGONIST; GUT MICROBIOTA DEPLETION; ENTERIC NERVOUS-SYSTEM; ACID-INDUCED COLITIS; CHAIN FATTY-ACIDS; NEURONAL SEROTONIN; REUPTAKE TRANSPORTER; DENDRITIC CELLS; MUCOSAL SEROTONIN;
D O I
10.3390/ijms22179487
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.
引用
收藏
页数:23
相关论文
共 157 条
[41]   Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats [J].
Fukumoto, S ;
Tatewaki, M ;
Yamada, T ;
Fujimiya, M ;
Mantyh, C ;
Voss, M ;
Eubanks, S ;
Harris, M ;
Pappas, TN ;
Takahashi, T .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 284 (05) :R1269-R1276
[42]   Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut [J].
Fung, Thomas C. ;
Vuong, Helen E. ;
Luna, Cristopher D. G. ;
Pronovost, Geoffrey N. ;
Aleksandrova, Antoniya A. ;
Riley, Noah G. ;
Vavilina, Anastasia ;
McGinn, Julianne ;
Rendon, Tomiko ;
Forrest, Lucy R. ;
Hsiao, Elaine Y. .
NATURE MICROBIOLOGY, 2019, 4 (12) :2064-2073
[43]   Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism [J].
Gao, Jing ;
Xu, Kang ;
Liu, Hongnan ;
Liu, Gang ;
Bai, Miaomiao ;
Peng, Can ;
Li, Tiejun ;
Yin, Yulong .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, 8
[44]   The serotonin signaling system: From basic understanding to drug development-for functional GI disorders [J].
Gershon, Michael D. ;
Tack, Jan .
GASTROENTEROLOGY, 2007, 132 (01) :397-414
[45]  
Gershon Michael D, 2012, Trans Am Clin Climatol Assoc, V123, P268
[46]   Serotonin Has a Key Role in Pathogenesis of Experimental Colitis [J].
Ghia, Jean-Eric ;
Li, Nan ;
Wang, Huaqing ;
Collins, Matthew ;
Deng, Yikang ;
El-Sharkawy, Rami T. ;
Cote, Francine ;
Mallet, Jacques ;
Khan, Waliul I. .
GASTROENTEROLOGY, 2009, 137 (05) :1649-1660
[47]   Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management [J].
Gros, Monica ;
Gros, Belen ;
Mesonero, Jose Emilio ;
Latorre, Eva .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (15)
[48]   Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice [J].
Gross, Erica R. ;
Gershon, Michael D. ;
Margolis, Kara G. ;
Gertsberg, Zoya V. ;
Cowles, Robert A. .
GASTROENTEROLOGY, 2012, 143 (02) :408-+
[49]   Serotonin 5-HT7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract [J].
Guseva, Daria ;
Holst, Katrin ;
Kaune, Beate ;
Meier, Martin ;
Keubler, Lydia ;
Glage, Silke ;
Buettner, Manuela ;
Bleich, Andre ;
Pabst, Oliver ;
Bachmann, Oliver ;
Ponimaskin, Evgeni G. .
INFLAMMATORY BOWEL DISEASES, 2014, 20 (09) :1516-1529
[50]   5-HT promotes pulmonary arterial smooth muscle cell proliferation through the TRPC channel [J].
Han Junli ;
Tian Hongyan ;
Liu Ya ;
Fan Fenling .
CELLULAR AND MOLECULAR BIOLOGY, 2018, 64 (13) :89-96