Prognostic Significance of p53 and KAI-1 Expression in Patients with Laryngeal Squamous Cell Carcinoma

被引：0

作者：

Re, Massimo ^{[1
]}

Magliulo, Giuseppe ^{[2
]}

Salvolini, Eleonora ^{[3
]}

Orciani, Monia ^{[3
]}

Gioacchini, Federico Maria ^{[1
]}

Goteri, Gala ^{[4
]}

Rubini, Corrado ^{[4
]}

机构：

[1] Polytech Univ Marche, Dept Clin Sci Otorhinolaryngol, I-60126 Ancona, Italy

[2] Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol, Rome, Italy

[3] Polytech Univ Marche, Dept Mol Pathol & Innovat Therapies Histol, I-60126 Ancona, Italy

[4] Polytech Univ Marche, Dept Neurosci Pathol Anat, I-60126 Ancona, Italy

来源：

ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY | 2010年 / 32卷 / 05期

关键词：

immunohistochemistry; KAI-1; larynx; p53; prognostic factors; squamous cell carcinoma; METASTASIS SUPPRESSOR; OVER-EXPRESSION; PANCREATIC-CANCER; LUNG-CANCER; CYCLIN D1; TUMOR; GENE; BCL-2; HEAD; SURVIVAL;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

OBJECTIVE: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma. STUDY DESIGN: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results. RESULTS: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers. CONCLUSION: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal spumous cell carcinoma who may benefit from more aggressive therapy or chemoprevention. (Anal Quant Cytol Histol 2010;32:247-253)

引用

页码：247 / 253

页数：7

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