Death receptors: Signaling and modulation

被引：4935

作者：

Ashkenazi, A ^{[1
]}

Dixit, VM ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, S San Francisco, CA 94080 USA

来源：

SCIENCE | 1998年 / 281卷 / 5381期

关键词：

D O I：

10.1126/science.281.5381.1305

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

引用

页码：1305 / 1308

页数：4

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