New Views of Old Proteins: Clarifying the Enigmatic Proteome

被引：16

作者：

Burnum-Johnson, Kristin E. ^{[1
]}

Conrads, Thomas P. ^{[2
]}

Drake, Richard R. ^{[3
]}

Herr, Amy E. ^{[4
]}

Iyengar, Ravi ^{[5
]}

Kelly, Ryan T. ^{[6
]}

Lundberg, Emma ^{[7
]}

MacCoss, Michael J. ^{[8
]}

Naba, Alexandra ^{[9
]}

Nolan, Garry P. ^{[10
]}

Pevzner, Pavel A. ^{[11
]}

Rodland, Karin D. ^{[12
]}

Sechi, Salvatore ^{[13
]}

Slavov, Nikolai ^{[14
]}

Spraggins, Jeffrey M. ^{[15
]}

Van Eyk, Jennifer E. ^{[16
]}

Vidal, Marc ^{[17
]}

Vogel, Christine ^{[18
]}

Walt, David R. ^{[19
]}

Kelleher, Neil L. ^{[20
]}

机构：

[1] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA

[2] Inova Hlth Syst, Inova Womens Serv Line, Falls Church, VA USA

[3] Med Univ South Carolina, Cell & Mol Pharmacol & Expt Therapeut, Charleston, SC USA

[4] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA USA

[5] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY USA

[6] Brigham Young Univ, Dept Chem & Biochem, Provo, UT USA

[7] KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden

[8] Univ Washington, Dept Genome Sci, Seattle, WA USA

[9] Univ Illinois, Dept Physiol & Biophys, Chicago, IL USA

[10] Stanford Univ, Dept Pathol, Stanford, CA USA

[11] Univ Calif San Diego, Dept Comp Sci & Engn, San Diego, CA USA

[12] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA USA

[13] NIDDKD, NIH, Bethesda, MD USA

[14] Northeastern Univ, Dept Bioengn, Boston, MA USA

[15] Vanderbilt Univ, Mass Spectrometry Res Ctr, Dept Cell & Dev Biol, Nashville, TN USA

[16] Cedars Sinai Med Ctr, Adv Clin Biosyst Inst, Dept Biomed Sci, Los Angeles, CA USA

[17] Harvard Univ, Dept Genet, Cambridge, MA USA

[18] NYU, Ctr Genom & Syst Biol, New York, NY USA

[19] Harvard Univ, Brigham & Womens Hosp, Harvard Med Sch, Dept Pathol,Wyss Inst, Boston, MA USA

[20] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

MOLECULAR & CELLULAR PROTEOMICS | 2022年 / 21卷 / 07期

基金：

瑞典研究理事会; 美国国家卫生研究院;

关键词：

IMAGING MASS-SPECTROMETRY; EXTRACELLULAR-MATRIX; SINGLE; QUANTIFICATION; STRATEGIES;

D O I：

10.1016/j.mcpro.2022.100254

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

引用

页数：13

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