Bimatoprost Versus Travoprost in an Egyptian Population: A Hospital-Based Prospective, Randomized Study

Purpose: To compare the efficacy of bimatoprost and travoprost on intraocular pressure (IOP) reduction in an Egyptian population. Methods: Patients with primary open-angle glaucoma or ocular hypertension were randomized to receive either bimatoprost 0.03% or travoprost 0.004% once daily. IOPs were measured at baseline; 2 weeks; and 1, 2, 4, and 6 months using Goldman applanation tonometery. Results: Seventy-two patients were included: 34 and 38 (P = 0.142) with a baseline mean IOP = 26.52 +/- 5.185 and 26.36 +/- 1.605mm Hg (P = 0.629) for bimatoprost and travoprost, respectively. Both drops provided statistically significant IOP reductions from baseline at all visits (P < 0.001). Bimatoprost provided greater (nonsignificant) mean IOP reductions from baseline than travoprost at each visit. Mean IOP reductions was 8.77mm Hg (33.39%) and 8.42mm Hg (31.54%) at 2 weeks (P - 0.703), and 8.47mm Hg (31.61%) and 7.84mm Hg (29.50%) at 6 months (P - 0.536) for bimatoprost and travoprost, respectively. IOPs at 2 weeks were <= 18mm Hg in 20 (58.8%) versus 19 (50%) eyes (P - 0.603), and <= 16mm Hg in 12 (35%) versus 12 (32%) eyes (P - 0.456); and at 6 months <= 18mm Hg in 22 (65%) versus 14 (37%) eyes (P = 0.045), and <= 16mm Hg in 12 (35%) versus 7 (18%) eyes (P = 0.037) for bimatoprost and travoprost, respectively. Ocular adverse and clinical success occurred equally with both drops. Conclusion: Both drops lowered IOP effectively but bimatoprost showed a greater non-significant reductions in mean IOP from baseline.