Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways

被引：21

作者：

Brown, Timothy M. ^{[1
]}

Allen, Annette E. ^{[1
]}

Wynne, Jonathan ^{[1
]}

Paul, David L. ^{[2
]}

Piggins, Hugh D. ^{[1
]}

Lucas, Robert J. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

VISION RESEARCH | 2011年 / 51卷 / 02期

基金：

英国惠康基金;

关键词：

Mouse; Scotopic; Melanopsin; Electroretinogram; Connexin; RETINAL GANGLION-CELLS; ADAPTED MOUSE RETINA; CONE BIPOLAR CELLS; MAMMALIAN RETINA; NUCLEUS; PHOTORECEPTORS; VISION; SIGNALS; PHOTOTRANSDUCTION; CONNEXIN36;

D O I：

10.1016/j.visres.2010.08.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36(-/-)) and carrying a mutation that disrupts cone phototransduction (Gnat2(cpfl3)). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：280 / 287

页数：8

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