Experimental Encephalomyocarditis Virus Infection in Small Laboratory Rodents

被引：15
作者：
Doi, K. [1 ,2 ]
机构：
[1] Nippon Inst Biol Sci, Tokyo 1980024, Japan
[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 2011年 / 144卷 / 01期
关键词：
encephalomyocarditis virus; pathogenesis; pathology; small laboratory rodents; CENTRAL-NERVOUS-SYSTEM; ACTIVATED PROTEIN-KINASE; EXPERIMENTAL VIRAL MYOCARDITIS; INDUCED DIABETES-MELLITUS; CONGESTIVE-HEART-FAILURE; NITRIC-OXIDE PRODUCTION; IN-SITU HYBRIDIZATION; EMC VIRUS; D-VARIANT; DBA/2; MICE;
D O I：
10.1016/j.jcpa.2010.05.001
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Encephalomyocarditis virus (EMCV) is a cardiovirus that belongs to the family Picornaviridac. EMCV is an important cause of acute myocarditis in piglets and of fetal death or abortion in pregnant sows. Small rodents, especially rats, have been suspected to be reservoir hosts or carriers. This virus also induces type 1 diabetes mellitus, encephalomyelitis, myocarditis, orchitis and/or sialodacryoadenitis in small laboratory rodents. This paper reviews the pathology and pathogenesis of experimental infection with EMCV in small laboratory rodents. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：25 / 40
页数：16
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